Agouridis Aris P, Mastori-Kourmpani Christina, Antoniou Polyna, Konstantinou Paschalis, Rizos Evangelos C, Tsioutis Constantinos
School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus.
Department of Internal Medicine, German Oncology Center, 4108 Limassol, Cyprus.
Pathogens. 2024 Mar 20;13(3):265. doi: 10.3390/pathogens13030265.
Beau's lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of this study is to systematically report all evidence on the association of Beau's lines with COVID-19 infection or vaccination against COVID-19.
PubMed and Scopus databases were searched up to January 2024 for articles reporting Beau's lines associated with COVID-19 infection or vaccination for COVID-19.
CRD42024496830.
PubMed search identified 299 records while Scopus search identified 18 records. After screening the bibliography, nine studies including 35 cases were included in our systematic review. The studies were reported from different areas around the world. Included studies documented Beau's lines following COVID-19 vaccination (two studies) or after COVID-19 infection (seven studies). High variability was recorded in onset and resolution times among included cases, averaging 3 months and 6 months after COVID-19 infection, respectively. In the two studies reporting Beau's lines after vaccination, onset was at 7 days and 6 weeks and resolution occurred after 8 and 17 weeks, respectively.
To the best of our knowledge, this is the first systematic review reporting the association of Beau's lines with COVID-19 infection and vaccination. Severe immune response can result in the formation of these nail disorders. Of importance, Beau's lines represent a potential indicator of prior severe COVID-19 infection or vaccination for COVID-19, as well as a sign of long COVID-19 syndrome.
博氏线是指甲板上的横向凹槽，由严重疾病后近端甲母质生长的短暂中断引起。本研究的目的是系统地报告所有关于博氏线与新冠病毒感染或新冠病毒疫苗接种之间关联的证据。
截至2024年1月，在PubMed和Scopus数据库中搜索报告与新冠病毒感染或新冠病毒疫苗接种相关的博氏线的文章。
CRD42024496830。
PubMed搜索识别出299条记录，Scopus搜索识别出18条记录。在筛选文献后，我们的系统评价纳入了9项研究，共35例病例。这些研究来自世界各地不同地区。纳入的研究记录了新冠病毒疫苗接种后（两项研究）或新冠病毒感染后（七项研究）出现的博氏线。纳入病例的发病和消退时间差异很大，新冠病毒感染后平均分别为3个月和6个月。在两项报告疫苗接种后出现博氏线的研究中，发病时间分别为7天和6周，消退时间分别为8周和17周。
据我们所知，这是第一项系统评价博氏线与新冠病毒感染和疫苗接种之间关联的研究。严重的免疫反应可导致这些指甲疾病的形成。重要的是，博氏线是既往严重新冠病毒感染或新冠病毒疫苗接种的潜在指标，也是新冠后综合征的一个迹象。
