School of Pharmacy, Southwest Minzu University, Chengdu, Sichuan 610225, China.
BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Food Funct. 2024 Apr 22;15(8):3897-3907. doi: 10.1039/d3fo03831a.
Quercetin is a unique bioactive flavonoid, and is an excellent antioxidant and has anti-tumor effects by regulating different tumor-related processes like proliferation, apoptosis, invasion, and spread. The latest investigations reveal that quercetin may have the capability to influence DNA methylation modification, one of the primary factors in the development of tumors. Despite the fact that quercetin has significant therapeutic properties, its use as an anti-tumor medicine is constrained by its poor solubility, short half-life, and ineffective tumor targeting. Here, we review the structure and properties of quercetin, its capacity for DNA methylation modification in tumors, and the possibility of nanoscale delivery of quercetin for future tumor treatment.
槲皮素是一种独特的生物活性类黄酮，具有出色的抗氧化能力，并通过调节增殖、凋亡、侵袭和扩散等不同的肿瘤相关过程发挥抗肿瘤作用。最新研究表明，槲皮素可能具有影响 DNA 甲基化修饰的能力，而 DNA 甲基化修饰是肿瘤发生的主要因素之一。尽管槲皮素有显著的治疗特性，但由于其溶解度差、半衰期短以及对肿瘤的靶向作用无效，其作为抗肿瘤药物的应用受到限制。在这里，我们综述了槲皮素的结构和性质、其在肿瘤中 DNA 甲基化修饰的能力，以及纳米尺度递送来实现未来肿瘤治疗的可能性。
