The Second People's Hospital of Huai'an, Huai'an, China; Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Biomed Pharmacother. 2020 Jan;121:109604. doi: 10.1016/j.biopha.2019.109604. Epub 2019 Nov 13.
Quercetin is a kind of flavonoid compounds that comes from nature and is widely existed in the daily diet. Previous studies have found that quercetin has many effects such as anti-inflammatory, anti-oxidation and anti-cancer. Both in vivo and in vitro experiments have demonstrated that quercetin can exert anti-tumor effects by altering cell cycle progression, inhibiting cell proliferation, promoting apoptosis, inhibiting angiogenesis and metastasis progression, and affecting autophagy. This review summarizes the evidence for the pharmacological potential and inhibition of quercetin on cancers, supporting the viewpoint that quercetin should be adequately considered as a therapeutic agent against various cancers.
槲皮素是一种天然存在的类黄酮化合物，广泛存在于日常饮食中。先前的研究发现，槲皮素有许多作用，如抗炎、抗氧化和抗癌。体内和体外实验均表明，槲皮素通过改变细胞周期进程、抑制细胞增殖、促进细胞凋亡、抑制血管生成和转移进展以及影响自噬来发挥抗肿瘤作用。本综述总结了槲皮素在癌症方面的药理潜力和抑制作用的证据，支持将槲皮素充分考虑作为治疗各种癌症的药物这一观点。
