Yang Aijuan, Wang Jiyun, Yang Wei, Yang Zhengfei, Zhang Liming, Li Hangying
People's Hospital of Ningxia Hui Autonomous Region Ningxia Medical University Yinchuan P. R. China.
School of Pharmacy Ningxia Medical University Yinchuan P. R. China.
Food Sci Nutr. 2025 Jul 10;13(7):e70500. doi: 10.1002/fsn3.70500. eCollection 2025 Jul.
Quercetin, a naturally occurring flavonoid with demonstrated antioxidant, anti-inflammatory, and anticancer properties, has emerged as a focal point in biomedical research. Despite extensive studies, a systematic bibliometric analysis of quercetin research remains lacking. To visualize research trends, collaboration networks, and knowledge domains of quercetin research, we analyzed the top 200 most-cited articles from the Web of Science Core Collection (2000-2023) using VOSviewer software to visualize research trends, collaboration networks, and knowledge domains. The analysis identified China ( = 44; 11,238 citations) and the United States ( = 33; 8254 citations) as the leading contributors, with Tokushima University emerging as the most productive institution ( = 6; 1800 citations). The most influential research team was the Wolffram, Siegfried, and Hollman, PCH group. The Journal of Agricultural and Food Chemistry emerged as the top publishing journal ( = 14; 3738 citations). Science mapping through keyword co-occurrence analysis identified four primary research hotspots: (1) molecular mechanisms and delivery systems, (2) therapeutic applications, (3) active constituents and analytical methods, and (4) metabolic and cellular regulation. Major research topics included cancer ( = 31; 7271 citations), antioxidant effects ( = 20; 6513 citations), and neurological diseases ( = 17; 3544 citations). The dominant research areas were biochemistry and molecular biology ( = 40; 9997 citations) and pharmacology and pharmacy ( = 39; 11,208 citations). The study maps the field's intellectual structure, collaboration dynamics, and developmental trajectories, providing clear identification of knowledge gaps and strategic direction for future research in this rapidly evolving field.
槲皮素是一种天然存在的黄酮类化合物，具有抗氧化、抗炎和抗癌特性，已成为生物医学研究的焦点。尽管进行了广泛研究，但仍缺乏对槲皮素研究的系统文献计量分析。为了可视化槲皮素研究的趋势、合作网络和知识领域，我们使用VOSviewer软件分析了科学网核心合集（2000 - 2023年）中被引用次数最多的前200篇文章，以可视化研究趋势、合作网络和知识领域。分析确定中国（= 44篇；11238次引用）和美国（= 33篇；8254次引用）是主要贡献者，德岛大学是产出最多的机构（= 6篇；1800次引用）。最具影响力的研究团队是沃尔夫勒姆、西格弗里德和霍尔曼的PCH团队。《农业与食品化学杂志》是发表文章最多的期刊（= 14篇；3738次引用）。通过关键词共现分析进行的科学图谱绘制确定了四个主要研究热点：（1）分子机制和递送系统，（2）治疗应用，（3）活性成分和分析方法，以及（4）代谢和细胞调节。主要研究主题包括癌症（= 31篇；7271次引用）、抗氧化作用（= 20篇；6513次引用）和神经疾病（= 17篇；3544次引用）。主导研究领域是生物化学与分子生物学（= 40篇；9997次引用）和药理学与药剂学（= 39篇；11208次引用）。该研究描绘了该领域的知识结构、合作动态和发展轨迹，为这个快速发展领域的未来研究明确了知识差距和战略方向。
