Han Zhuo, Zhao Chao, Li Yuhua, Xiao Meng, Yang Yuewei, Zhao Yizhuo, Liu Chunyu, Liu Juan, Li Penghui
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China.
Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin 300384, China.
Toxics. 2024 Mar 10;12(3):209. doi: 10.3390/toxics12030209.
The effects of air pollution on physical health are well recognized, with many studies revealing air pollution's effects on vision disorder, yet no relationship has been established. Therefore, a meta-analysis was carried out in this study to investigate the connection between vision disorder and ambient particles (diameter ≤ 2.5 µm (PM), diameter ≤ 10 µm (PM)) and gaseous pollutants (nitrogen dioxide (NO), sulfur dioxide (SO), carbon monoxide (CO), Ozone (O)). Twelve relevant studies published by 26 February 2024 were identified in three databases. A pooled odds ratios (ORs) of 95% confidence intervals (CIs) were obtained using random-effects meta-analysis models. Meta-analysis results revealed that for every 10 µg/m increase in PM and NO exposure, a substantially higher incidence of vision disorder was observed (OR = 1.10; 95% CI: 1.01, 1.19; OR = 1.08, 95% CI: 1.00, 1.16). No significant correlation existed between exposure to PM, SO and CO and vision disorder. However, O exposure was negatively associated with vision disorder. In addition, subgroup analyses revealed that PM exposure was significantly correlated with the risk of glaucoma and age-related macular degeneration and that children and adolescents were more susceptible to NO and PM than adults. Overall, exposure to air pollutants, especially PM and NO, may increase the incidence of vision disorder.
空气污染对身体健康的影响已得到广泛认可，许多研究揭示了空气污染对视力障碍的影响，但尚未建立起两者之间的关联。因此，本研究进行了一项荟萃分析，以调查视力障碍与环境颗粒物（直径≤2.5微米（PM）、直径≤10微米（PM））和气态污染物（二氧化氮（NO）、二氧化硫（SO）、一氧化碳（CO）、臭氧（O））之间的联系。在三个数据库中确定了截至2024年2月26日发表的12项相关研究。使用随机效应荟萃分析模型获得了95%置信区间（CI）的合并优势比（OR）。荟萃分析结果显示，PM和NO暴露每增加10微克/立方米，视力障碍的发病率就会显著升高（OR = 1.10；95% CI：1.01，1.19；OR = 1.08，95% CI：1.00，1.16）。PM、SO和CO暴露与视力障碍之间不存在显著相关性。然而，O暴露与视力障碍呈负相关。此外，亚组分析显示，PM暴露与青光眼和年龄相关性黄斑变性的风险显著相关，儿童和青少年比成年人更容易受到NO和PM的影响。总体而言，暴露于空气污染物，尤其是PM和NO，可能会增加视力障碍的发病率。
