• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Multi-Omics and Single-Cell Omics: New Tools in Drug Target Discovery.多组学与单细胞组学：药物靶点发现的新工具
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):759-762. doi: 10.1161/ATVBAHA.124.320686. Epub 2024 Mar 27.
2
Advances in Integrated Multi-omics Analysis for Drug-Target Identification.整合多组学分析在药物靶点识别中的进展。
Biomolecules. 2024 Jun 14;14(6):692. doi: 10.3390/biom14060692.
3
Computational Methods for Single-cell Multi-omics Integration and Alignment.单细胞多组学整合与对齐的计算方法。
Genomics Proteomics Bioinformatics. 2022 Oct;20(5):836-849. doi: 10.1016/j.gpb.2022.11.013. Epub 2022 Dec 26.
4
Advancing Physiology with Expanded Multi-Omics.通过扩展多组学推进生理学研究。
Function (Oxf). 2022 Jun 20;3(4):zqac031. doi: 10.1093/function/zqac031. eCollection 2022.
5
Spatial transformation of multi-omics data unlocks novel insights into cancer biology.多组学数据的空间转换揭示了癌症生物学的新见解。
Elife. 2023 Sep 5;12:RP87133. doi: 10.7554/eLife.87133.
6
Top Trends in Multiomics Research: Evaluation of 52 Published Studies and New Ways of Thinking Terminology and Visual Displays.多组学研究的主要趋势：52 项已发表研究的评估及术语和可视化呈现的新思维方式。
OMICS. 2021 Nov;25(11):681-692. doi: 10.1089/omi.2021.0160. Epub 2021 Oct 22.
7
Multi-omics characterization and machine learning of lung adenocarcinoma molecular subtypes to guide precise chemotherapy and immunotherapy.肺腺癌分子亚型的多组学特征分析及机器学习以指导精准化疗和免疫治疗
Front Immunol. 2024 Nov 28;15:1497300. doi: 10.3389/fimmu.2024.1497300. eCollection 2024.
8
Application of omics- and multi-omics-based techniques for natural product target discovery.基于组学和多组学技术的天然产物靶标发现应用。
Biomed Pharmacother. 2021 Sep;141:111833. doi: 10.1016/j.biopha.2021.111833. Epub 2021 Jun 25.
9
Benchmarking multi-omics integrative clustering methods for subtype identification in colorectal cancer.用于结直肠癌亚型识别的多组学整合聚类方法的基准测试
Comput Methods Programs Biomed. 2025 Apr;261:108603. doi: 10.1016/j.cmpb.2025.108603. Epub 2025 Jan 13.
10
Spatial integration of multi-omics single-cell data with SIMO.利用单输入多输出实现多组学单细胞数据的空间整合。
Nat Commun. 2025 Feb 1;16(1):1265. doi: 10.1038/s41467-025-56523-4.

引用本文的文献

1
Identifying novel therapeutic targets for non-alcoholic fatty liver disease using bioinformatics approaches: from drug repositioning to traditional Chinese medicine.利用生物信息学方法鉴定非酒精性脂肪性肝病的新型治疗靶点：从药物重新定位到中药
Front Bioinform. 2025 Aug 26;5:1613985. doi: 10.3389/fbinf.2025.1613985. eCollection 2025.

本文引用的文献

1
Machine learning-based integration of network features and chemical structure of compounds for SARS-CoV-2 drug effect analysis.基于机器学习的网络特征和化合物化学结构整合用于 SARS-CoV-2 药物效果分析。
CPT Pharmacometrics Syst Pharmacol. 2024 Feb;13(2):257-269. doi: 10.1002/psp4.13076. Epub 2023 Nov 20.
2
High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases.高维免疫表型分析揭示了未确诊的炎症性和自身免疫性疾病患者的免疫细胞异常。
J Clin Invest. 2023 Dec 15;133(24):e169619. doi: 10.1172/JCI169619.
3
Phenomics and Robust Multiomics Data for Cardiovascular Disease Subtyping.表型组学和稳健的多组学数据在心血管疾病亚型分类中的应用。
Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):1111-1123. doi: 10.1161/ATVBAHA.122.318892. Epub 2023 May 25.
4
Nutrient concentrations in food display universal behaviour.食物中的营养浓度呈现出普遍的规律。
Nat Food. 2022 May;3(5):375-382. doi: 10.1038/s43016-022-00511-0. Epub 2022 May 24.
5
Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases.多器官单细胞分析揭示了一种潜在的个性化免疫疾病治疗的开/关开关系统。
Cell Rep Med. 2023 Mar 21;4(3):100956. doi: 10.1016/j.xcrm.2023.100956. Epub 2023 Feb 28.
6
Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization.通过联合药理学评估和细胞网络优先级确定严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的有效抑制剂。
iScience. 2022 Sep 16;25(9):104925. doi: 10.1016/j.isci.2022.104925. Epub 2022 Aug 13.
7
A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets.基于动态单细胞的数字孪生框架，用于优先考虑疾病基因和药物靶点。
Genome Med. 2022 May 6;14(1):48. doi: 10.1186/s13073-022-01048-4.
8
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes.基于网络的个体化互作组学在肥厚型心肌病精准医学中的应用及其对其他临床表型的影响。
Nat Commun. 2021 Feb 8;12(1):873. doi: 10.1038/s41467-021-21146-y.
9
Robustness and lethality in multilayer biological molecular networks.多层生物分子网络的稳健性和致命性。
Nat Commun. 2020 Nov 27;11(1):6043. doi: 10.1038/s41467-020-19841-3.
10
Network-based approach to prediction and population-based validation of in silico drug repurposing.基于网络的药物重定位预测方法及基于人群的验证。
Nat Commun. 2018 Jul 12;9(1):2691. doi: 10.1038/s41467-018-05116-5.

Multi-Omics and Single-Cell Omics: New Tools in Drug Target Discovery.

作者信息

Loscalzo Joseph

机构信息

Division of Cardiovascular Medicine and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

出版信息

Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):759-762. doi: 10.1161/ATVBAHA.124.320686. Epub 2024 Mar 27.

DOI:10.1161/ATVBAHA.124.320686
PMID:38536899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10977648/
Abstract
摘要