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BMJ Open. 2022 Dec 5;12(12):e057844. doi: 10.1136/bmjopen-2021-057844.
3
The Association of Perceived, Internalized, and Enacted HIV Stigma With Medication Adherence, Barriers to Adherence, and Mental Health Among Young People Living With HIV in Zambia.赞比亚感染艾滋病毒的年轻人中,感知到的、内化的和表现出的艾滋病毒耻辱感与药物依从性、依从性障碍及心理健康之间的关联
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Lancet HIV. 2022 Nov;9(11):e751-e759. doi: 10.1016/S2352-3018(22)00237-5.
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如果我被那个女孩拒绝了怎么办?我宁愿停止服药”:津巴布韦感染艾滋病毒的 18-29 岁青年成年人坚持接受抗逆转录病毒治疗的障碍和促进因素。

"What if I got rejected by the girl? I would rather stop the pills": barriers and facilitators of adherence to antiretroviral therapy for emerging adults aged 18-29 living with HIV in Zimbabwe.

机构信息

Health Services and Population Research Department, King's College London, London, UK.

University of Zimbabwe, Harare, Zimbabwe.

出版信息

AIDS Care. 2024 Jul;36(sup1):168-178. doi: 10.1080/09540121.2024.2332462. Epub 2024 Mar 27.

DOI:10.1080/09540121.2024.2332462
PMID:38537178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11283961/
Abstract

Emerging adults aged 18-29 have high rates of viral non-suppression, and poorer adherence to ART when compared to older adults. Semi-structured interviews were conducted with 24 emerging adults in Zimbabwe who had a recent history of viral non-suppression, to explore barriers and facilitators of adherence to ART. Interviews were coded using inductive thematic analysis. The mean age of participants was 23, 65% were male, and 79% reported acquiring HIV at birth. Twelve barriers to adherence were identified. Hiding HIV status due to the possible negative consequences of disclosure had a significant impact on adherence to ART. This was particularly important for emerging adults navigating starting intimate relationships. Being away from home, poverty, poor mental health, isolation, significant life events, alcohol, health systems barriers, and stigma were reported as barriers to adherence. Support from peers and family after disclosure of HIV status, phone-based reminders, problem-solving strategies to adhere, knowing others living with HIV, acted as facilitators to adherence to ART. Beliefs about medicines and relationships with health care providers acted as both barriers and facilitators to adherence. Interventions to reduce stigma, foster peer support, and therapy for common mental disorders could facilitate emerging adults aged 18-29 to adhere to ART.

摘要

18-29 岁的青年成年人病毒抑制率高,与老年成年人相比,他们对 ART 的依从性更差。本研究对津巴布韦最近病毒未抑制的 24 名青年成年人进行了半结构化访谈,以探讨他们对 ART 依从性的障碍和促进因素。使用归纳主题分析对访谈进行了编码。参与者的平均年龄为 23 岁,65%为男性,79%报告在出生时感染了 HIV。确定了 12 个与依从性相关的障碍。由于披露 HIV 状态可能带来的负面后果,隐藏 HIV 状态对 ART 的依从性有重大影响。对于正在开始亲密关系的青年成年人来说,这一点尤为重要。离家出走、贫困、心理健康状况差、孤立、重大生活事件、酒精、卫生系统障碍和耻辱感是报告的依从性障碍。在 HIV 状态披露后,来自同伴和家人的支持、基于电话的提醒、坚持服药的解决问题策略、认识其他 HIV 感染者,都对坚持 ART 起到了促进作用。对药物的信念和与医疗保健提供者的关系既是依从性的障碍,也是依从性的促进因素。减少耻辱感、培养同伴支持和治疗常见精神障碍的干预措施可以促进 18-29 岁的青年成年人坚持接受 ART 治疗。