Jinniu Maternity and Child Health Hospital of Chengdu, 610000 Chengdu, Sichuan, China.
Front Biosci (Landmark Ed). 2024 Mar 11;29(3):97. doi: 10.31083/j.fbl2903097.
Basic leucine zipper and W2 domains 2 (), a member of the basic domain leucine zipper superfamily of transcription factors, has been implicated in the development and progression of various cancers. However, the precise biological role of in pan-cancer datasets remains to be explored. This study aimed to assess the prognostic significance of and its immune-related signatures in various tumors.
Our study investigated the expression, epigenetic modifications, and clinical prognostic relevance of using multi-omics data in different cancer types. Additionally, the immunological characteristics, tumor stemness, drug sensitivity, and correlation of with immunotherapy response were explored. Finally, experiments were conducted to assess the impact of knockdown on Hela cells, a cell line derived from cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC).
exhibited elevated expression levels in various tumor tissues and significantly impacted the prognosis of different cancer types. emerged as an independent prognostic factor in CESC. We found that copy number amplification and methylation levels of were associated with its mRNA expression. Immunological analyses revealed that shapes a non-inflamed immunosuppressive tumor microenvironment across multiple cancers. Furthermore, our cell experiments demonstrated that knockdown reduced proliferation, migration, and apoptosis activities in CESC cells.
promotes cancer progression by shaping a non-inflamed immunosuppressive tumor microenvironment. Additionally, was shown to significantly influence the proliferation, migration, and apoptosis of CESC cells.
碱性亮氨酸拉链和 W2 结构域蛋白 2（）是碱性亮氨酸拉链转录因子超家族的成员之一，与多种癌症的发生和发展有关。然而，在泛癌症数据集中的作用仍有待探索。本研究旨在评估在各种肿瘤中的预后意义及其免疫相关特征。
我们的研究使用多组学数据研究了在不同癌症类型中表达、表观遗传修饰和临床预后相关性。此外，还探讨了的免疫特征、肿瘤干性、药物敏感性以及与免疫治疗反应的相关性。最后，进行了实验，以评估下调对 Hela 细胞（源自宫颈鳞状细胞癌和宫颈内膜腺癌（CESC）的细胞系）的影响。
在各种肿瘤组织中呈现出升高的表达水平，并且显著影响了不同癌症类型的预后。在 CESC 中，被鉴定为独立的预后因素。我们发现的拷贝数扩增和甲基化水平与 mRNA 表达相关。免疫分析表明，在多种癌症中，塑造了一种非炎症性的免疫抑制性肿瘤微环境。此外，我们的细胞实验表明，下调可降低 CESC 细胞的增殖、迁移和凋亡活性。
通过塑造非炎症性免疫抑制性肿瘤微环境促进癌症进展。此外，还显著影响 CESC 细胞的增殖、迁移和凋亡。
