Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DK-2800, Denmark.
Trends Immunol. 2024 Apr;45(4):225-227. doi: 10.1016/j.it.2024.03.001. Epub 2024 Mar 26.
Snakebite envenomings kill ~100 000 victims each year and leave many more with permanent sequelae. Antivenoms have been available for more than 125 years but are in need of innovation. A new study by Khalek et al. highlights broadly neutralizing human monoclonal antibodies (mAbs) that might be used to develop recombinant antivenoms with superior therapeutic benefits.
每年有近 10 万人死于蛇伤,还有更多人因此留下永久性后遗症。抗蛇毒血清已经问世 125 年有余,但仍需要创新。Khalek 等人的一项新研究强调了具有广泛中和作用的人源单克隆抗体(mAbs),这些抗体可能被用于开发具有更好治疗效果的重组抗蛇毒血清。