Complement and Inflammation Research Section, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Trends Immunol. 2024 Apr;45(4):228-230. doi: 10.1016/j.it.2024.03.003. Epub 2024 Mar 26.
Complement, traditionally perceived as a liver-derived and plasma-operative guardian against bloodborne pathogens, is increasingly recognized as a local and central player in tissue immunity. Two recent studies, by Xu et al. and Wu et al., validate this concept in the mouse gut, where extrahepatic, intestine-produced, and/or operative C3 protects against enteric infections.
补体，传统上被认为是一种肝脏来源的、在血浆中发挥作用的、抵御血源性病原体的物质，现在越来越被认为是组织免疫中的一个局部和中央的参与者。最近由 Xu 等人和 Wu 等人进行的两项研究在小鼠肠道中验证了这一概念，即肝脏外的、肠道产生的和/或发挥作用的 C3 可抵抗肠道感染。
