Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), #54 Youdian Road, Shangcheng District, Hangzhou, Zhejiang 310000, China.
Department of First Clinical Medical College, Zhejiang Chinese Medical University, #548 Binwen Road, Binjiang District, Hangzhou, Zhejiang 310000, China.
Hum Mol Genet. 2024 Jun 21;33(13):1186-1193. doi: 10.1093/hmg/ddae056.
Melanoma, renowned for its aggressive behavior and resistance to conventional treatments, stands as a formidable challenge in the oncology landscape. The dynamic and complex interplay between cancer cells and the tumor microenvironment has gained significant attention, revealing Melanoma-Associated Fibroblasts (MAFs) as central players in disease progression. The heterogeneity of MAFs endows them with a dual role in melanoma. This exhaustive review seeks to not only shed light on the multifaceted roles of MAFs in orchestrating tumor-promoting inflammation but also to explore their involvement in antitumor immunity. By unraveling novel mechanisms underlying MAF functions, this review aims to provide a comprehensive understanding of their impact on melanoma development. Additionally, it delves into the potential of leveraging MAFs for innovative immunotherapeutic strategies, offering new avenues for enhancing treatment outcomes in the challenging realm of melanoma therapeutics.
黑色素瘤以其侵袭性和对常规治疗的耐药性而闻名，是肿瘤学领域的一个巨大挑战。癌细胞与肿瘤微环境之间的动态和复杂相互作用引起了广泛关注，揭示了黑色素瘤相关成纤维细胞（MAFs）在疾病进展中的核心作用。MAFs 的异质性使它们在黑色素瘤中具有双重作用。这篇全面的综述不仅旨在阐明 MAFs 在调节肿瘤促进炎症中的多方面作用，还探讨了它们在抗肿瘤免疫中的参与。通过揭示 MAF 功能的新机制，本综述旨在全面了解它们对黑色素瘤发展的影响。此外，它还探讨了利用 MAF 进行创新免疫治疗策略的潜力，为黑色素瘤治疗这一极具挑战性的领域提供了提高治疗效果的新途径。
