Muruzábal Cecilia, Vicente Lorea, Escolano Taravillo Lucía, Bravo Queipo de Llano Blanca, Calvo Cristina, García López Hortelano Milagros
Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain.
La Paz Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
Children (Basel). 2024 Mar 21;11(3):374. doi: 10.3390/children11030374.
There are few data on yellow fever (YF) and hepatitis A (HA) off-label vaccination. Given the rising trend of travel to endemic countries, there is a growing necessity to broaden vaccination coverage among the pediatric population. For this reason, we aim to assess the adverse effects associated with off-label vaccination, with the ultimate purpose of expanding the vaccine spectrum. We analyzed ambispectively ninety-four children under 12 months of age who received YF or HA off-label vaccines. The YF vaccine was administered to children aged 6-9 months and those allergic to eggs (with a prior negative prick test and no history of anaphylaxis), while the HA vaccine was given to children aged 6-12 months. Overall, 71 (75%) were vaccinated against YF, and 57 (60%) against HA; 34 against both. All of them fulfilled off-label vaccination criteria. No immediate adverse effects (AEs) were reported. Mild common AEs (diarrhea, fever, or malaise) were experienced by 10.8% of patients within 10 days after vaccination. The rate of AEs associated with off-label vaccination for HA and YF is low, suggesting that the vaccines could be considered safe.
关于黄热病（YF）和甲型肝炎（HA）非标签接种疫苗的数据较少。鉴于前往流行国家旅行的趋势不断上升，扩大儿科人群的疫苗接种覆盖率的必要性日益增加。因此，我们旨在评估与非标签接种疫苗相关的不良反应，最终目的是扩大疫苗谱。我们对94名12个月以下接受YF或HA非标签疫苗接种的儿童进行了双向分析。YF疫苗接种给6至9个月大且对鸡蛋过敏（皮试阴性且无过敏反应史）的儿童，而HA疫苗接种给6至12个月大的儿童。总体而言，71名（75%）接种了YF疫苗，57名（60%）接种了HA疫苗；34名同时接种了两种疫苗。他们均符合非标签接种标准。未报告立即出现的不良反应（AE）。10.8%的患者在接种后10天内出现轻度常见AE（腹泻、发热或不适）。HA和YF非标签接种疫苗的AE发生率较低，表明这些疫苗可被视为安全的。
