Rodríguez-Ibarria Nieves G, Pinar Beatriz, García Laura, Cabezón Auxiliadora, Rey-Baltar Dolores, Rodríguez-Melcón Juan Ignacio, Lloret Marta, Lara Pedro C
Radiation Oncology Department, Dr. Negrin University Hospital Las Palmas GC, 35010 Las Palmas de Gran Canaria, Spain.
Medical School, Las Palmas University, 35001 Las Palmas de Gran Canaria, Spain.
Cancers (Basel). 2024 Mar 13;16(6):1138. doi: 10.3390/cancers16061138.
Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 182 low-risk breast cancer patients treated by BCS in the four university hospitals of the province of Las Palmas and treated with APBI using interstitial multicatheter brachytherapy were included in this study. After a mean follow-up for survivors of 10 years, the treatment was shown to be safe, as no severe acute/late toxicity (grade ≥ 3) was observed. The 10-year IBTR was 1.7% (95%CI: 0.7-2.7%), and the cause-specific survival was 94.9% (95%CI: 93.2-96.6%). We suggest that multicatheter brachytherapy after BCS is safe and effective in early breast cancer patients.
早期乳腺癌患者通常采用保乳手术（BCS）及术后放疗进行治疗。近年来，部分乳腺照射已被广泛接受。2008年12月至2017年12月期间，本研究纳入了拉斯帕尔马斯省四家大学医院中182例接受BCS治疗并采用组织间多导管近距离放疗进行加速部分乳腺照射（APBI）的低风险乳腺癌患者。对幸存者进行平均10年的随访后发现，该治疗方法是安全的，因为未观察到严重的急性/晚期毒性反应（≥3级）。10年局部区域复发率（IBTR）为1.7%（95%置信区间：0.7 - 2.7%），特定病因生存率为94.9%（95%置信区间：93.2 - 96.6%）。我们认为，BCS术后多导管近距离放疗对早期乳腺癌患者是安全有效的。
