Akdag Delal, Rasmussen Allan, Nielsen Susanne Dam, Møller Dina Leth, Togsverd-Bo Katrine, Wenande Emily, Haedersdal Merete, Pommergaard Hans-Christian
Department of Surgery and Transplantation, Centre for Cancer and Organ Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Hepatic Malignancy Surgical Research Unit (HEPSURU), Department of Surgery and Transplantation, Centre for Cancer and Organ Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Cancers (Basel). 2024 Mar 20;16(6):1224. doi: 10.3390/cancers16061224.
(1) Background: Skin cancer is the most common cancer in transplant recipients. Timely and regular screening may reduce advanced disease. The study aimed to determine referral rates to screening, the incidence, and risk factors of skin cancer in a Danish liver transplant recipient cohort. (2) Methods: All first-time liver transplant recipients, >18 years old, attending outpatient care between January 2018 and December 2021 were included. The referral rates and incidence of skin cancer/preneoplastic lesions were calculated. Risk factors were assessed using Cox regression analyses. (3) Results: Of the 246 included recipients, 219 (89.0%) were referred to screening, and 102 skin cancer/preneoplastic lesions were diagnosed in 32 (15.6%) recipients. The IR of any skin cancer/preneoplastic lesion was 103.2 per 1000 person-years. BCC was the most frequent skin cancer followed by SCC, IR: 51.3 vs. 27.1 per 1000 person-years, respectively. No cases of MM were observed. The IR of actinic keratosis and Bowen's Disease were 48.1 vs. 13.2 per 1000 person-years, respectively. Time since transplantation was independently associated with skin cancer/preneoplastic lesions, HR (95%CI) 2.81 (1.64-4.80). (4) Conclusions: The study determined the incidence and risk factors of skin cancer/preneoplastic lesions in liver transplant recipients enrolled in a screening program, while demonstrating a high screening referral rate.
（1）背景：皮肤癌是移植受者中最常见的癌症。及时且定期的筛查可能会减少晚期疾病的发生。本研究旨在确定丹麦肝移植受者队列中皮肤癌的筛查转诊率、发病率及危险因素。（2）方法：纳入2018年1月至2021年12月期间年龄大于18岁、接受门诊治疗的所有首次肝移植受者。计算皮肤癌/癌前病变的转诊率和发病率。使用Cox回归分析评估危险因素。（3）结果：在纳入的246名受者中，219名（89.0%）被转诊进行筛查，32名（15.6%）受者被诊断出102例皮肤癌/癌前病变。任何皮肤癌/癌前病变的发病率为每1000人年103.2例。基底细胞癌是最常见的皮肤癌，其次是鳞状细胞癌，发病率分别为每1000人年51.3例和27.1例。未观察到黑色素瘤病例。光化性角化病和鲍温病的发病率分别为每1000人年48.1例和13.2例。移植后的时间与皮肤癌/癌前病变独立相关，风险比（95%置信区间）为2.81（1.64 - 4.80）。（4）结论：本研究确定了参加筛查项目的肝移植受者中皮肤癌/癌前病变的发病率及危险因素，同时显示出较高的筛查转诊率。
