Department of Dermatology, Royal Darwin Hospital, Tiwi, Northwest Territories, Australia,
Department of Dermatology, St. Vincent's Hospital Sydney, Sydney, New South Wales, Australia.
Dermatology. 2021;237(4):629-634. doi: 10.1159/000510055. Epub 2020 Sep 17.
Research examining skin disease in heart and lung transplant recipients in Australia is limited. This study aims to determine the spectrum of skin diseases encountered in Australian heart and lung transplant recipients, their effect on quality of life, and potential risk factors for skin cancer.
Ninety-four participants were recruited from an Australian heart and lung transplant centre between March and December 2016. The participants were asked to fill out a questionnaire which included the Dermatology Life Quality Index and were examined for malignant and non-malignant skin disease. The association of study variables with the presence of skin cancer and Dermatology Life Quality Index score were examined using logistic regression analysis.
A dermatological diagnosis was made in 82 patients (87%). Actinic keratosis was the most common diagnosis, affecting 50 participants (53%), followed by skin cancer (41; 44%) and warts (14; 15%). Other non-malignant skin diseases were less common. Risk factors associated with skin cancer on multivariate modelling included age at transplantation and a history of ≥5 post-transplant skin cancers. Skin disease had a negative effect on the quality of life of a minority of patients.
Actinic keratosis and skin cancer are very frequent in Australian heart and lung transplant recipients and more common than non-malignant skin diseases. Routine dermatological surveillance at regular intervals is advised.
在澳大利亚，研究心脏和肺移植受者皮肤疾病的工作有限。本研究旨在确定澳大利亚心脏和肺移植受者中所遇到的皮肤疾病谱、它们对生活质量的影响，以及皮肤癌的潜在危险因素。
2016 年 3 月至 12 月期间，从澳大利亚的一个心肺移植中心招募了 94 名参与者。参与者被要求填写一份调查问卷，其中包括皮肤病生活质量指数（Dermatology Life Quality Index），并对恶性和非恶性皮肤疾病进行检查。使用逻辑回归分析检查研究变量与皮肤癌和皮肤病生活质量指数评分的存在之间的关联。
82 名患者（87%）做出了皮肤病诊断。光化性角化病是最常见的诊断，影响 50 名患者（53%），其次是皮肤癌（41；44%）和疣（14；15%）。其他非恶性皮肤疾病则较少见。多变量模型中与皮肤癌相关的危险因素包括移植时的年龄和移植后≥5 次皮肤癌病史。皮肤疾病对少数患者的生活质量有负面影响。
光化性角化病和皮肤癌在澳大利亚的心脏和肺移植受者中非常常见，且比非恶性皮肤疾病更为常见。建议定期进行常规皮肤科监测。
