鲁拉西酮在治疗精神分裂症患者抑郁症状中的作用：一项综述
The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review.
作者信息
Fiorillo Andrea, Sampogna Gaia, Albert Umberto, Bondi Emi, De Giorgi Serafino, Fagiolini Andrea, Pompili Maurizio, Serafini Gianluca, Volpe Umberto, Vita Antonio
机构信息
Department of Psychiatry, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.
出版信息
Brain Sci. 2024 Feb 28;14(3):225. doi: 10.3390/brainsci14030225.
BACKGROUND
Schizophrenia is a severe mental disorder characterized by positive, negative, affective, and cognitive symptoms. Affective symptoms in patients with schizophrenia have traditionally been overlooked or even neglected because they are not considered as fundamental as positive and negative symptoms in the choice of medication.
METHODS
This paper aims to systematically evaluate the efficacy and safety of lurasidone in the treatment of depressive symptoms of schizophrenia.
RESULTS
Lurasidone appears to be particularly effective on the depressive symptomatology of schizophrenia while also alleviating the positive and negative symptoms associated with the illness.
CONCLUSIONS
The efficacy of lurasidone in treating patients with first-episode psychosis who present with predominant depressive symptoms suggests that this medication may be a valuable treatment option not only for established cases of schizophrenia but also for individuals in the early stages of the illness. The good tolerability of lurasidone is an important factor that may positively influence treatment decisions.
背景
精神分裂症是一种严重的精神障碍，其特征为阳性、阴性、情感及认知症状。精神分裂症患者的情感症状传统上一直被忽视甚至被忽略，因为在药物选择方面，它们不像阳性和阴性症状那样被视为根本性症状。
方法
本文旨在系统评估鲁拉西酮治疗精神分裂症抑郁症状的疗效和安全性。
结果
鲁拉西酮似乎对精神分裂症的抑郁症状特别有效，同时还能减轻与该疾病相关的阳性和阴性症状。
结论
鲁拉西酮在治疗以抑郁症状为主的首发精神病患者中的疗效表明，这种药物不仅对于确诊的精神分裂症病例，而且对于疾病早期阶段的个体而言，可能都是一种有价值的治疗选择。鲁拉西酮良好的耐受性是可能对治疗决策产生积极影响的一个重要因素。
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