Carbone Manuel Glauco, Merati Tommaso, Miccichè Rossella, Callegari Camilla, Tripodi Beniamino, Tagliarini Claudia, Maremmani Icro, Marazziti Donatella
Department of Medicine and Surgery, Division of Psychiatry, University of Insubria, Varese, Italy.
Saint Camillus International University of Health and Medical Sciences, Via di Sant'Alessandro 8, Rome 00131, Italy.
Case Rep Psychiatry. 2025 Aug 11;2025:5541100. doi: 10.1155/crps/5541100. eCollection 2025.
Capgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her deceased husband had been replaced by an imposter. The clinical presentation was complex, including pronounced sleep disturbances, cognitive decline, behavioral anomalies, and visual hallucinations, necessitating a thorough differential diagnosis process. We detail the patient's history, clinical findings, and the investigations undertaken, including brain imaging and cognitive assessments. The management approach involved a personalized treatment plan integrating Lithium sulfate, Citalopram, and Lurasidone, alongside psychosocial interventions. While a partial improvement was observed, the case underscores the complexities of managing CS in the context of LBD, highlighting the need for tailored and multidisciplinary approaches to care. This case contributes to the limited literature on CS in LBD and provides practical insights for clinicians managing similar presentations.
卡普格拉综合征(CS)带来了独特的诊断和管理挑战,尤其是与神经退行性疾病相关时。本病例报告描述了一名73岁女性,被诊断为路易体痴呆(LBD),并出现了CS,表现为妄想认为她已故的丈夫被一个冒名顶替者取代。临床表现复杂,包括明显的睡眠障碍、认知衰退、行为异常和视幻觉,需要进行全面的鉴别诊断过程。我们详细介绍了患者的病史、临床发现以及所进行的检查,包括脑部成像和认知评估。管理方法包括一个个性化的治疗方案,整合了硫酸锂、西酞普兰和鲁拉西酮,同时还有社会心理干预措施。虽然观察到部分改善,但该病例强调了在LBD背景下管理CS的复杂性,突出了需要有针对性的多学科护理方法。本病例丰富了关于LBD中CS的有限文献,并为管理类似表现的临床医生提供了实际见解。