Kozlov L V, Rostovtseva L I, Lomaka T S, Sutovskaia N S, Sorokina I B
Bioorg Khim. 1985 Nov;11(11):1510-8.
Along with complement activation by the classical pathway, blastolysin, an antitumor and adjuvant preparation of Lactobacillus bulgaricus peptidoglycans, effectively inhibits the transformation of C3 in to C5 convertase. Values of inhibition maximum and dissociation constants of the reversible C3b-acceptor complex for blastolysin and main immunological active structural moieties of peptidoglycans (GMDP, MDP) and their inactive carbohydrate components (N-acetylglucosaminyl-N-acetylmuramic acid, N-acetylglucosamine, and N-acetylmuramic acid) have been determined. Immunostimulator concentrations for blastolysin, GMDP, and MDP in inhibition of the C5 convertase formation (C3b binding) correlate with their doses in vivo (animal blood), displaying antitumor activity.
除了通过经典途径激活补体外，溶菌素（一种保加利亚乳杆菌肽聚糖的抗肿瘤和佐剂制剂）可有效抑制C3转化为C5转化酶。已经测定了溶菌素、肽聚糖主要免疫活性结构部分（GMDP、MDP）及其无活性碳水化合物成分（N-乙酰葡糖胺-N-乙酰胞壁酸、N-乙酰葡糖胺和N-乙酰胞壁酸）的可逆C3b受体复合物的最大抑制值和解离常数。溶菌素、GMDP和MDP在抑制C5转化酶形成（C3b结合）方面的免疫刺激剂浓度与其在体内（动物血液）的剂量相关，显示出抗肿瘤活性。
