Zakharova N S, Shepeleva I B, Kalina N G, Britsina M V, Elkina S I, Andronova T M, Ermolova E V
Zh Mikrobiol Epidemiol Immunobiol. 1991 Jan(1):52-5.
The action of peptidoglycans (PG) of different origin has been experimentally studied in vivo. In these experiments PG of bacterial origin, such as blastolysin (BL), and synthetic PG, viz. muramyldipeptide (MDP) and its analog glucosaminylmuramyldipeptide (GMDP) have been used. Their toxicity, allergenic action, their effect on the phagocytic activity of peritoneal exudate macrophages (PEM), the accumulation of antibody-producing cells in the spleen, antibody titer in the blood serum and delayed hypersensitivity to nonbacterial antigens have been determined. As revealed in this study, BL does not differ from MDP in its toxicity and allergenic action. The phagocytic activity of PEM under the influence of BL only insignificantly differs from their activity under the influence of MDP, but is lower than under the influence of GMDP. The adjuvant action of BL is somewhat higher than that of synthetic PG.
已在体内对不同来源的肽聚糖（PG）的作用进行了实验研究。在这些实验中，使用了细菌来源的PG，如胚泡溶解素（BL），以及合成PG，即胞壁酰二肽（MDP）及其类似物葡糖胺基胞壁酰二肽（GMDP）。测定了它们的毒性、致敏作用、对腹膜渗出液巨噬细胞（PEM）吞噬活性的影响、脾脏中抗体产生细胞的积累、血清中的抗体滴度以及对非细菌抗原的迟发型超敏反应。如本研究所示，BL在毒性和致敏作用方面与MDP没有差异。仅在BL影响下的PEM吞噬活性与在MDP影响下的活性相比差异不显著，但低于在GMDP影响下的活性。BL的佐剂作用略高于合成PG。
