Bezrukov M V, Andronova T M, Reshetova O S, Mal'kova V P, Sorokina I B
Bioorg Khim. 1987 Mar;13(3):386-94.
Active principle of blastolysin, comprising ca. 40% of the total weight of Lactobacillus bulgaricus cell wall preparation, has been isolated and structurally studied by chemical and spectral methods. The substance a glycopeptide with Mr aa. 10,000, consists of two tetrasaccharide moieties connected by oligopeptide bridges; glycerophosphate, glucose, and galactose moieties are also attached to N-acetylmuramyl residue of the peptidoglucan core. Tetrasaccharide-containing muramylpeptides were shown to be responsible for the antitumour activity.
溶菌素的活性成分约占保加利亚乳杆菌细胞壁制剂总重量的40%，已通过化学和光谱方法进行分离和结构研究。该物质是一种分子量约为10,000的糖肽，由通过寡肽桥连接的两个四糖部分组成；甘油磷酸、葡萄糖和半乳糖部分也连接到肽聚糖核心的N-乙酰胞壁酰残基上。含四糖的胞壁酰肽被证明具有抗肿瘤活性。
