Husson-van Vliet J, Roussel P
Comput Methods Programs Biomed. 1985 Dec;21(3):167-72. doi: 10.1016/0169-2607(85)90001-x.
A method has been developed, based on the Newton-Raphson iterative procedure, for calculating the concentration of viral suspensions from the dose-response data yielded by the cytopathic effect assays. The computation method provides the maximum likelihood estimate with its 95% approximated confidence limits, and determines the value of chi 2 for testing the goodness of the fit. A program for a Hewlett-Packard 41C calculator is presented which is suitable to most experimental situations.
