Longo G, Matucci M, Morfini M, Vannini S, Messori A
Drug Intell Clin Pharm. 1984 Sep;18(9):726-30. doi: 10.1177/106002808401800911.
We developed a calculator program to individualize Factor VIII dosage on the basis of the concentration-time data obtained after a single test-dose. The program is designed for the Hewlett-Packard 41-CV calculator. The calculation procedure is the 1977 version of the Sawchuk and Zaske method. The program performs model parameter estimation through a nonlinear iterative least-squares technique (the modified Gauss-Newton method). We tested our program in three patients with classic hemophilia who required multiple-dose treatment with Factor VIII. In each patient, individual kinetic parameters were estimated from the serial plasma levels measured after the test-dose. The predicted concentration-time curve resulting from all the administered doses was calculated based on the estimated kinetic parameters. Good agreement between predicted and measured levels during the multiple-dose regimen was observed in all patients.
我们开发了一个计算器程序，可根据单次试验剂量后获得的浓度-时间数据来个体化调整凝血因子VIII的剂量。该程序是为惠普41-CV计算器设计的。计算过程采用的是1977年版的索丘克和扎斯克方法。该程序通过非线性迭代最小二乘法技术（改进的高斯-牛顿法）进行模型参数估计。我们在3例需要多次注射凝血因子VIII治疗的典型血友病患者中测试了我们的程序。在每例患者中，根据试验剂量后测得的系列血浆水平估算个体动力学参数。基于估算的动力学参数计算出所有给药剂量后的预测浓度-时间曲线。在所有患者的多剂量治疗方案中，均观察到预测水平与实测水平之间具有良好的一致性。
