Zaroulis C G, Pivacek L E, Lowrie G B, Valeri C R
Transfusion. 1979 Jul-Aug;19(4):420-5. doi: 10.1046/j.1537-2995.1979.19479250179.x.
Baboons were bled one-third of their blood volume and then transfused with an equivalent volume of compatible donor red blood cells with 160 per cent of normal 2,3-diphosphoglycerate (2,3-DPG) levels and improved capacity to release oxygen to tissue. The mixture of baboon donor-recipient red blood cells in the circulation had a 2,3-DPG level of 130 per cent of normal. After transfusion, the baboon's inspired oxygen was first lowered from 21 to 10 per cent to produce severe arterial hypoxemia with a PO2 tension of less than 40 mm Hg for two hours and then restored to 21 per cent. Lactic acidemia occurred when the alveolar oxygen tension was reduced so as to produce an arterial oxygen tension of less than 40 mm Hg, even though oxygen consumption was maintained. The data suggest that when red blood cells with normal or improved oxygen delivering capacity are transfused to patients, the alveolar oxygen tension should be sufficient to maintain an arterial oxygen tension of greater than 40 mm Hg.
将狒狒的三分之一血容量进行采血，然后输入等量的具有正常2,3 - 二磷酸甘油酸（2,3 - DPG）水平160%且向组织释放氧气能力增强的相容供体红细胞。循环中狒狒供体 - 受体红细胞混合物的2,3 - DPG水平为正常水平的130%。输血后，首先将狒狒吸入的氧气从21%降至10%，持续两小时以产生严重的动脉低氧血症，动脉血氧分压（PO2）低于40 mmHg，然后恢复至21%。即使维持了氧消耗，当肺泡氧分压降低以产生低于40 mmHg的动脉氧分压时，仍会发生乳酸性酸中毒。数据表明，当向患者输入具有正常或改善的氧气输送能力的红细胞时，肺泡氧分压应足以维持大于40 mmHg的动脉氧分压。
