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叙事性预警:对精神分裂症中言语紊乱之前主题的定性分析。

Narrative Forewarnings: A Qualitative Analysis of the Themes Preceding Disorganized Speech in Schizophrenia.

作者信息

Bettis Robert J, Faith Laura A, Beard Ashlynn M, Whan Brailee A, Hegwood Ceouna M, Monette Mahogany A, Myers Evan J, Linton Imani S, Leonhardt Bethany L, Salyers Michelle P, Minor Kyle S

机构信息

Department of Psychology, Indiana University-Indianapolis, Indianapolis, IN 46202, USA.

Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37240, USA.

出版信息

Behav Sci (Basel). 2024 Mar 6;14(3):212. doi: 10.3390/bs14030212.

DOI:10.3390/bs14030212
PMID:38540515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10968572/
Abstract

Disorganized speech is a critical barrier to recovery in schizophrenia, with profound negative impacts on one's ability to engage with the world. Despite the limited efficacy of existing treatments in addressing disorganization, a qualitative analysis of what leads to disorganization in patient narratives has been lacking. This study addresses this gap through inductive thematic analysis of 30 narrative interviews with individuals with schizophrenia, matched based on whether Formal Thought Disorder (FTD) is present. Through this analysis, we identified four core themes (alienation, interpersonal tension, personal benchmarks, and adverse experiences) and eight subthemes. Our findings suggest that disorganization may serve as a protective mechanism against psychological distress and highlight how the severity of FTD influences these themes. Alienation, particularly due to illness-related stigma, emerged more prominently in those with FTD. The themes of personal benchmarks and interpersonal tension pointed towards a heightened sensitivity to social interactions and self-perception among those with schizophrenia. Adverse experiences, encompassing past challenges, suggest a potential link between trauma and symptom exacerbation. Our qualitative analysis of what themes precede disorganized speech has implications for tailoring psychotherapy. By considering an individual's specific triggers and level of disorganization, therapy may be more effectively targeted to improve recovery-based outcomes. By identifying themes within patient narratives, this study advances our understanding of the qualitative aspects preceding disorganized speech in schizophrenia, paving the way for more personalized and effective recovery-focused interventions.

摘要

言语紊乱是精神分裂症康复的关键障碍,对患者与外界交流的能力产生深远负面影响。尽管现有治疗方法在解决言语紊乱方面效果有限,但对于患者叙述中导致言语紊乱的因素缺乏定性分析。本研究通过对30名精神分裂症患者的叙述性访谈进行归纳主题分析来填补这一空白,这些访谈对象根据是否存在形式思维障碍(FTD)进行匹配。通过该分析,我们确定了四个核心主题(疏离感、人际紧张、个人标准和不良经历)以及八个子主题。我们的研究结果表明,言语紊乱可能是一种抵御心理困扰的保护机制,并突出了FTD的严重程度如何影响这些主题。疏离感,尤其是由于与疾病相关的污名化,在患有FTD的患者中更为突出。个人标准和人际紧张的主题表明,精神分裂症患者对社交互动和自我认知的敏感度更高。不良经历,包括过去的挑战,表明创伤与症状加重之间可能存在联系。我们对言语紊乱之前出现的主题进行的定性分析对量身定制心理治疗具有启示意义。通过考虑个体的特定触发因素和言语紊乱程度,治疗可能更有效地针对改善基于康复的结果。通过识别患者叙述中的主题,本研究推进了我们对精神分裂症言语紊乱之前定性方面的理解,为更个性化和有效的以康复为重点的干预措施铺平了道路。

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本文引用的文献

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The Role of Childhood Trauma in Affective Stress Recovery in Early Psychosis: An Experience Sampling Study.童年创伤在早期精神病情感应激恢复中的作用:一项经验抽样研究。
Schizophr Bull. 2024 Jul 27;50(4):891-902. doi: 10.1093/schbul/sbae004.
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Meta-analysis of the relationship between metacognition and disorganized symptoms in psychosis.关于精神病元认知与紊乱症状之间关系的荟萃分析。
Schizophr Res. 2024 Feb;264:178-187. doi: 10.1016/j.schres.2023.12.009. Epub 2023 Dec 27.
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Latent Factors of Language Disturbance and Relationships to Quantitative Speech Features.语言障碍的潜在因素及其与定量语音特征的关系。
Schizophr Bull. 2023 Mar 22;49(Suppl_2):S93-S103. doi: 10.1093/schbul/sbac145.
4
Mild vs. moderate: How behavioral speech measures predict metacognitive capacity across different levels of formal thought disorder.轻度与中度:行为言语测量如何预测不同程度的形式思维障碍下的元认知能力。
J Psychiatr Res. 2023 Jan;157:43-49. doi: 10.1016/j.jpsychires.2022.11.013. Epub 2022 Nov 17.
5
Clinical and computational speech measures are associated with social cognition in schizophrenia spectrum disorders.临床和计算语音测量与精神分裂症谱系障碍中的社会认知相关。
Schizophr Res. 2023 Sep;259:28-37. doi: 10.1016/j.schres.2022.06.012. Epub 2022 Jul 11.
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Stuck Inside: How Social Functioning in Schizophrenia Changed During the COVID-19 Pandemic.被困家中:精神分裂症患者的社会功能在 COVID-19 大流行期间发生的变化。
J Nerv Ment Dis. 2022 Dec 1;210(12):915-924. doi: 10.1097/NMD.0000000000001558. Epub 2022 Jun 14.
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Natural Language Processing markers in first episode psychosis and people at clinical high-risk.首发精神病和临床高危人群中的自然语言处理标志物。
Transl Psychiatry. 2021 Dec 13;11(1):630. doi: 10.1038/s41398-021-01722-y.
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The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study.精神病早期形式思维障碍的临床相关性:来自 PRONIA 研究的结果。
Eur Arch Psychiatry Clin Neurosci. 2022 Apr;272(3):403-413. doi: 10.1007/s00406-021-01327-y. Epub 2021 Sep 17.
9
Personalizing interventions using real-world interactions: Improving symptoms and social functioning in schizophrenia with tailored metacognitive therapy.利用真实世界的互动来实现个性化干预:通过量身定制的元认知疗法改善精神分裂症的症状和社会功能。
J Consult Clin Psychol. 2022 Jan;90(1):18-28. doi: 10.1037/ccp0000672. Epub 2021 Aug 19.
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