Department of Cognitive Neuroscience, Neuroscience Division, Institute for Cellular Physiology, National Autonomous University of Mexico, Coyoacán, México; email:
Department of Physiology, School of Medicine, National Autonomous University of Mexico, Coyoacán, México.
Annu Rev Physiol. 2023 Feb 10;85:293-316. doi: 10.1146/annurev-physiol-030222-012349.
The ability to detect stimuli from the environment plays a pivotal role in our survival. The molecules that allow the detection of such signals include ion channels, which are proteins expressed in different cells and organs. Among these ion channels, the transient receptor potential (TRP) family responds to the presence of diverse chemicals, temperature, and osmotic changes, among others. This family of ion channels includes the TRPV or vanilloid subfamily whose members serve several physiological functions. Although these proteins have been studied intensively for the last two decades, owing to their structural and functional complexities, a number of controversies regarding their function still remain. Here, we discuss some salient features of their regulation in light of these controversies and outline some of the efforts pushing the field forward.
从环境中检测刺激的能力对我们的生存起着至关重要的作用。能够检测这些信号的分子包括离子通道，它们是在不同的细胞和器官中表达的蛋白质。在这些离子通道中，瞬时受体电位 (TRP) 家族对各种化学物质、温度和渗透压变化等的存在作出反应。该离子通道家族包括 TRPV 或香草素亚家族，其成员具有多种生理功能。尽管这些蛋白质在过去的二十年中得到了深入研究，但由于其结构和功能的复杂性，关于它们功能的一些争议仍然存在。在这里，我们根据这些争议讨论了它们调节的一些显著特征，并概述了推动该领域发展的一些努力。
