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新冠病毒感染后持续存在的嗅觉和味觉功能障碍

Persistent Olfactory and Taste Dysfunction after COVID-19.

作者信息

Buksinska Malgorzata, Skarzynski Piotr Henryk, Raj-Koziak Danuta, Gos Elzbieta, Talarek Malgorzata

机构信息

Otorhinolaryngosurgery Clinic, World Hearing Center, Institute of Physiology and Pathology of Hearing, 05-830 Kajetany, Poland.

Department of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, 05-830 Kajetany, Poland.

出版信息

Life (Basel). 2024 Feb 28;14(3):317. doi: 10.3390/life14030317.

Abstract

(1) Background: One of the possible symptoms of COVID-19 is a sudden loss of smell and taste. The main aim of the study was to evaluate the severity of post-COVID-19 olfactory dysfunction (OD). A secondary aim was to assess the relationship between OD and gustatory (taste) dysfunction (GD). Margins: 2.5 cm (1 inch) at top, bottom, right, and left. (2) Methods: The study group consisted of 81 subjects (16 men and 65 women) aged between 12 and 73 years. All of the patients presented to a center for subjective OD associated with COVID-19. They were tested with a Sniffin' Sticks test (SST) for OD and a Taste Strip test (TS) for GD. (3) Anosmia was present in 18 participants (22%), hyposmia in 52 (64%), and normosmia in 11 (14%). Some 36% of the patients reported imaginary smells (phantosmia), but it did not correlate with olfactory sensitivity. Comparing the different parts of the SST showed that subjects scored lowest on the threshold part of the test. The results of the discrimination and identification parts of the test were better, implying that if the stimulus is intense enough, incorrect discrimination and identification of odors is less frequent. A sweet taste was the easiest to recognize (78% could do so), while the most difficult to recognize was salty (68%). There were weak and statistically non-significant correlations between olfactory and taste dysfunction. (4) Conclusions: The results suggest that post-COVID-19 olfactory dysfunction was more peripheral than central. Testing patients for the severity of post-COVID-19 OD may help clinicians treat the condition. Because there is no fully effective treatment, research on post-COVID-19 OD is needed.

摘要

(1) 背景:新型冠状病毒肺炎(COVID-19)可能出现的症状之一是嗅觉和味觉突然丧失。本研究的主要目的是评估COVID-19后嗅觉功能障碍(OD)的严重程度。次要目的是评估OD与味觉功能障碍(GD)之间的关系。页边距:上下左右各2.5厘米(1英寸)。(2) 方法:研究组由81名年龄在12至73岁之间的受试者组成(16名男性和65名女性)。所有患者均因与COVID-19相关的主观性OD就诊于某中心。他们接受了用于检测OD的嗅觉棒测试(SST)和用于检测GD的味觉试纸测试(TS)。(3) 18名参与者(22%)存在嗅觉丧失,52名(64%)存在嗅觉减退,11名(14%)嗅觉正常。约36%的患者报告有幻嗅(嗅觉幻觉),但这与嗅觉敏感性无关。比较SST的不同部分发现,受试者在测试的阈值部分得分最低。测试的辨别和识别部分结果较好,这意味着如果刺激足够强烈,气味辨别和识别错误的情况就较少发生。甜味最容易识别(78%的人能识别),而最难识别的是咸味(68%)。嗅觉和味觉功能障碍之间存在微弱且无统计学意义的相关性。(4) 结论:结果表明,COVID-19后嗅觉功能障碍更多是外周性而非中枢性的。检测COVID-19后OD的严重程度可能有助于临床医生治疗该病症。由于尚无完全有效的治疗方法,因此需要对COVID-19后OD进行研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d70/10970909/64f6a7d1dace/life-14-00317-g001.jpg

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