Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
Int J Mol Sci. 2024 Mar 15;25(6):3333. doi: 10.3390/ijms25063333.
Metagenomic sequencing has emerged as a transformative tool in infectious disease diagnosis, offering a comprehensive and unbiased approach to pathogen detection. Leveraging international standards and guidelines is essential for ensuring the quality and reliability of metagenomic sequencing in clinical practice. This review explores the implications of international standards and guidelines for the application of metagenomic sequencing in infectious disease diagnosis. By adhering to established standards, such as those outlined by regulatory bodies and expert consensus, healthcare providers can enhance the accuracy and clinical utility of metagenomic sequencing. The integration of international standards and guidelines into metagenomic sequencing workflows can streamline diagnostic processes, improve pathogen identification, and optimize patient care. Strategies in implementing these standards for infectious disease diagnosis using metagenomic sequencing are discussed, highlighting the importance of standardized approaches in advancing precision infectious disease diagnosis initiatives.
宏基因组测序在传染病诊断中已成为一种变革性的工具，为病原体检测提供了全面和无偏倚的方法。利用国际标准和指南对于确保宏基因组测序在临床实践中的质量和可靠性至关重要。这篇综述探讨了国际标准和指南对宏基因组测序在传染病诊断中应用的影响。通过遵循既定的标准，如监管机构和专家共识所概述的标准，医疗保健提供者可以提高宏基因组测序的准确性和临床实用性。将国际标准和指南纳入宏基因组测序工作流程可以简化诊断过程，提高病原体鉴定，并优化患者护理。讨论了在使用宏基因组测序进行传染病诊断时实施这些标准的策略，强调了标准化方法在推进精准传染病诊断计划中的重要性。
