Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, 72076 Tübingen, Germany.
Centre of Excellence for Eating Disorders (KOMET), 72076 Tübingen, Germany.
Nutrients. 2024 Mar 19;16(6):891. doi: 10.3390/nu16060891.
The microbiota-gut-brain axis may play a role in the pathophysiology of anorexia nervosa (AN). Here, the relationship between the gastrointestinal microbiota and symptoms of depression, anxiety, and eating disorder pathology in patients with AN before ( = 55) and after weight restoration ( = 44) was investigated by reanalyzing the data of the MICROBIAN study. The gastrointestinal microbiota was analyzed using 16S rRNA amplicon sequencing. Symptoms of anxiety disorder, depression, and the severity of the eating disorder were measured by validated questionnaires. All analyses were adjusted for the body mass index (BMI). Several significant findings between psychological parameters and the gastrointestinal microbiota were not evident after controlling for the BMI. No differences in alpha and beta diversity between groups of higher and lower symptom severity levels for depression and anxiety were found. Positive associations between species of and and depression symptoms, and between the phylum Firmicutes and anxiety symptoms were observed after rehabilitation, respectively. A positive correlation was found between propionate and acetate levels and the reduction of depression severity during inpatient treatment. Accounting for the weight status when analyzing the relationship between psychological parameters and the gastrointestinal microbiota in patients with underweight is important since the BMI may be the driver for many observed changes.
肠道微生物群-肠道-大脑轴可能在神经性厌食症 (AN) 的病理生理学中起作用。在这里，通过重新分析 MICROBIAN 研究的数据，研究了 AN 患者在体重恢复前后（=55）胃肠道微生物群与抑郁、焦虑和饮食障碍病理症状之间的关系。使用 16S rRNA 扩增子测序分析胃肠道微生物群。使用经过验证的问卷测量焦虑症、抑郁症和饮食障碍的严重程度。所有分析均根据体重指数 (BMI) 进行调整。在控制 BMI 后，心理参数与胃肠道微生物群之间的一些显著关联并不明显。在抑郁和焦虑症状严重程度较高和较低的组之间，未发现 alpha 和 beta 多样性存在差异。在康复后观察到 和 物种与抑郁症状之间呈正相关，厚壁菌门与焦虑症状之间呈正相关。住院治疗期间，丙酸和乙酸盐水平与抑郁严重程度的降低呈正相关。在分析体重不足患者的心理参数与胃肠道微生物群之间的关系时，考虑体重状况很重要，因为 BMI 可能是许多观察到的变化的驱动因素。
