神经性厌食症与微生物组：系统评价与批判性评估。
Anorexia nervosa and microbiota: systematic review and critical appraisal.
机构信息
Departamento de Psicología Clínica Y Psicobiología, Facultad de Psicología, Universidad de Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain.
Unidad Venres Clínicos, Facultad de Psicologıa, Universidad de Santiago de Compostela, Campus Vida, 15782, Santiago de Compostela, Spain.
出版信息
Eat Weight Disord. 2023 Feb 8;28(1):1. doi: 10.1007/s40519-023-01529-4.
PURPOSE
Recent studies have reported a gut microbiota imbalance or dysbiosis associated with anorexia nervosa (AN), which has prompted an appraisal of its aetiological role, and the reformulation of AN as a metabo-psychiatric disorder. Thus, the aim of this paper was to critically review the current scientific findings regarding the role of microbiota in anorexia nervosa.
METHODS
A systematic study of peer-reviewed literature published in four databases between 2009 and 2022 was conducted according to PRISMA guidelines. Both human and animal studies were included.
RESULTS
A total of 18 studies were included. In animal models, both the preclinical and clinical findings were inconsistent regarding microbiota composition, faecal metabolite concentrations, and the effects of human faecal microbiota transplants.
CONCLUSION
The methodological limitations, lack of standardisation, and conceptual ambiguity hinder the analysis of microbiota as a key explanatory factor for AN.
LEVEL OF EVIDENCE
Level I, systematic review.
目的
最近的研究报告称，厌食症（AN）与肠道微生物群失衡或失调有关，这促使人们对其病因学作用进行评估，并将 AN 重新定义为一种代谢-精神障碍。因此，本文旨在批判性地回顾当前关于微生物群在厌食症中作用的科学发现。
方法
根据 PRISMA 指南，对 2009 年至 2022 年期间在四个数据库中发表的同行评议文献进行了系统研究。纳入了人体和动物研究。
结果
共纳入 18 项研究。在动物模型中，关于微生物群组成、粪便代谢物浓度以及人类粪便微生物群移植的影响，临床前和临床研究结果均不一致。
结论
方法学限制、缺乏标准化和概念上的模糊性阻碍了将微生物群作为 AN 的关键解释因素进行分析。
证据水平
一级，系统评价。
Zotero 插件