Andreis Uilian, Américo Madileine F, Corá Luciana A, Oliveira Ricardo B, Baffa Oswaldo, Miranda José Ricardo A
Departamento de Física e Biofísica, IBB, São Paulo State University-UNESP, Botucatu, São Paulo, Brazil.
Physiol Meas. 2008 Sep;29(9):1023-31. doi: 10.1088/0967-3334/29/9/002. Epub 2008 Aug 13.
Association techniques could be the answer for evaluating electromechanical coupling and gastric emptying under basal conditions and after administration of drugs. Electrogastrography (EGG) and alternating current biosusceptometry (ACB) emerged due to their interesting nature, noninvasiveness and low cost. The aims were to examine in dogs the effect of erythromycin on gastric emptying by ACB and electrical and motor responses to erythromycin and propranolol by ACB and EGG respectively. Twelve beagle dogs ingested a solid test meal on separate days. Under anesthesia, gastric motility was evaluated by EGG and ACB after erythromycin and propranolol administration. Without anesthesia, gastric emptying was assessed under basal conditions and after erythromycin by ACB. ACB and EGG showed a strong temporal correlation. Erythromycin and propranolol presented the same profile with different power ratios; the amplitude increased whereas frequency decreased. Also, erythromycin administration hastened gastric emptying while reducing the orocaecal transit time. There is a demand for reliable, easy-to-perform and comfortable techniques to record gastric emptying and gastric activity in medicine and veterinary practice. In summary, the association of ACB with EGG accompanied by an appropriate animal model is promising for evaluating effects of drugs in gastric myoelectrical and contractile activity.
关联技术可能是评估基础条件下以及给药后机电耦合和胃排空情况的解决方案。胃电图（EGG）和交流电生物电阻抗测量法（ACB）因其有趣的特性、非侵入性和低成本而应运而生。目的是分别通过ACB研究红霉素对犬胃排空的影响，以及通过ACB和EGG研究红霉素和普萘洛尔对电反应和运动反应的影响。12只比格犬在不同日期摄入固体试验餐。在麻醉状态下，给予红霉素和普萘洛尔后，通过EGG和ACB评估胃动力。在非麻醉状态下，通过ACB评估基础条件下以及给予红霉素后的胃排空情况。ACB和EGG显示出很强的时间相关性。红霉素和普萘洛尔呈现出相同的特征，但功率比不同；振幅增加而频率降低。此外，给予红霉素可加快胃排空，同时缩短口盲肠转运时间。在医学和兽医实践中，需要可靠、易于操作且舒适的技术来记录胃排空和胃活动。总之，ACB与EGG相结合并辅以适当的动物模型，有望用于评估药物对胃肌电和收缩活动的影响。
