Viral Special Pathogens Branch, The Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30329, USA.
Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Monteagudo 2510, Pergamino 2700, Argentina.
Viruses. 2024 Feb 22;16(3):340. doi: 10.3390/v16030340.
Following an Argentine Hemorrhagic Fever (AHF) outbreak in the early 1990s, a rodent survey for Junín virus, a New World Clade B arenavirus, in endemic areas of Argentina was conducted. Since 1990, INEVH has been developing eco-epidemiological surveillance of rodents, inside and outside the Argentine Hemorrhagic Fever endemic area. Samples from rodents captured between 1993 and 2019 that were positive for Arenavirus infection underwent Sanger and unbiased, Illumina-based high-throughput sequencing, which yielded 5 complete and 88 partial genomes. Previously, 11 genomes representing four species of New World arenavirus Clade C existed in public records. This work has generated 13 novel genomes, expanding the New World arenavirus Clade C to 24 total genomes. Additionally, two genomes exhibit sufficient genetic diversity to be considered a new species, as per ICTV guidelines (proposed name ). The 13 novel genomes exhibited reassortment between the small and large segments in New World . This work demonstrates that Clade C infections circulate broadly among species in the Argentine Hemorrhagic Fever endemic area; however, the risk for Clade C human infection is currently unknown.
在 20 世纪 90 年代初阿根廷发生出血热疫情后，对阿根廷出血热流行地区的新型世界 B 群沙粒病毒（Junín 病毒）进行了啮齿动物调查。自 1990 年以来，INEVH 一直在对阿根廷出血热流行地区内外的啮齿动物进行生态流行病学监测。1993 年至 2019 年间捕获的对沙粒病毒感染呈阳性的啮齿动物样本进行了 Sanger 和无偏 Illumina 高通量测序，产生了 5 个完整和 88 个部分基因组。此前，公共记录中已有代表新型世界沙粒病毒 C 群的 4 个种的 11 个基因组。这项工作产生了 13 个新基因组，使新型世界沙粒病毒 C 群增加到 24 个总基因组。此外，根据 ICTV 指南（暂定名称），两个基因组显示出足够的遗传多样性，可被视为新物种。13 个新基因组在新型世界中显示出小片段和大片段之间的重组。这项工作表明，C 群感染在阿根廷出血热流行地区的种间广泛传播；然而，目前尚不清楚 C 群感染是否会对人类造成风险。
