Ezerskyte Egle, Morkvenas Augustas, Venius Jonas, Sakirzanovas Simas, Karabanovas Vitalijus, Katelnikovas Arturas, Klimkevicius Vaidas
Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania.
Biomedical Physics Laboratory, National Cancer Institute, Baublio 3b, LT-08406 Vilnius, Lithuania.
ACS Appl Nano Mater. 2024 Mar 5;7(6):6185-6195. doi: 10.1021/acsanm.3c06111. eCollection 2024 Mar 22.
The demand for multimodal nanomaterials has intensified in recent years driven by the need for ultrasensitive bioimaging probes and accurate temperature monitoring in biological objects. Among the different multimodal nanomaterials that have been extensively studied in the past decade, upconverting nanoparticles are among the most promising. In this paper, we report the synthesis of upconverting nanoparticles with complex core-shell compositions, capable of being excited by 808 or 980 nm laser irradiation and exhibiting a good MRI response. The synthesized nanoparticles also demonstrated high colloidal stability in both aqueous and biological media as well as temperature-sensing capabilities, including the physiological range. Furthermore, the upconversion nanoparticles exhibited significantly lower cytotoxicity for HEK293T cells than the commercially available MRI contrast agent Gd-DTPA.
近年来，由于对超灵敏生物成像探针的需求以及对生物物体进行精确温度监测的需求，对多模态纳米材料的需求日益增加。在过去十年中广泛研究的不同多模态纳米材料中，上转换纳米粒子是最有前途的材料之一。在本文中，我们报道了具有复杂核壳组成的上转换纳米粒子的合成，该纳米粒子能够被808或980 nm激光照射激发，并表现出良好的MRI响应。合成的纳米粒子在水性和生物介质中均表现出高胶体稳定性以及温度传感能力，包括生理范围内的温度传感能力。此外，与市售的MRI造影剂Gd-DTPA相比，上转换纳米粒子对HEK293T细胞的细胞毒性显著更低。
