Khan Haysum, Afreen Mahrukh, Khan Abdullah, Ali Malik Saif, Bhatti Mohammad Imran
Neurological Surgery, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, PAK.
Neurosurgery, Shifa International Hospital Islamabad, Islamabad, PAK.
Cureus. 2024 Feb 25;16(2):e54901. doi: 10.7759/cureus.54901. eCollection 2024 Feb.
Astroblastoma, a rare glial tumor of the central nervous system, presents diagnostic and therapeutic challenges due to its low incidence and variable clinical presentations. In this case study, we present the case of an 11-year-old boy with high-grade astroblastoma, highlighting the complexities in diagnosis and treatment. The clinical presentation initially involved right-sided motor weakness, which, after undergoing a brain MRI, revealed a large solid cystic mass in the left parietal lobe. Histopathological examination after undergoing surgery confirmed an astroblastoma with high-grade features, characterized by increased cellularity and high mitotic activity. Immunostaining patterns supported the glial origin of the tumor. Gross total resection remains the primary approach for its treatment, but adjuvant therapies for high-grade astroblastomas are still evolving, offering potential life-changing possibilities for the future. Due to its rarity, collecting sufficient data to develop an effective treatment protocol for this uncommon tumor is very challenging. This case underscores the importance of combined efforts and ongoing research to effectively navigate the diagnosis and treatment of astroblastoma.
成星形细胞瘤是一种罕见的中枢神经系统胶质肿瘤，由于其发病率低和临床表现多样，在诊断和治疗方面存在挑战。在本病例研究中，我们介绍了一名患有高级别成星形细胞瘤的11岁男孩的病例，突出了诊断和治疗中的复杂性。临床表现最初为右侧肢体运动无力，经脑部磁共振成像（MRI）检查后，发现左顶叶有一个巨大的实性囊性肿块。手术后的组织病理学检查证实为具有高级别特征的成星形细胞瘤，其特征为细胞增多和高有丝分裂活性。免疫染色模式支持肿瘤的胶质起源。肉眼全切仍然是其主要治疗方法，但高级别成星形细胞瘤的辅助治疗仍在不断发展，为未来提供了改变生活的可能性。由于其罕见性，收集足够的数据以制定针对这种罕见肿瘤的有效治疗方案极具挑战性。本病例强调了联合努力和持续研究对于有效指导成星形细胞瘤诊断和治疗的重要性。
