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慢性滥用苯丙胺类兴奋剂后出现的早发性痴呆。

Young-onset dementia following chronic abuse of amphetamine-type stimulants.

作者信息

Alamri Sultan H

机构信息

Sultan H. Alamri, MBBS Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Neuroscience and Geroscience Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Pak J Med Sci. 2024 Mar-Apr;40(4):779-781. doi: 10.12669/pjms.40.4.8737.

Abstract

Young-onset dementia (YOD) is influenced by various risk factors, including substance abuse. In this report, we present the case of a 54-year-old man who developed YOD following prolonged abuse of amphetamine-type stimulants. The patient exhibited insidious cognitive decline over a three-year period before seeking medical attention. Neuroimaging revealed atrophy of the temporal lobe, suggesting a connection between amphetamine-induced neurotoxicity and the cognitive abnormalities observed in the patient condition. Our case highlights the importance of considering amphetamine-type stimulants as potential risk factors for YOD and emphasizes the need to recognize cognitive impairment resulting from substance abuse. Additionally, we look into relevant literature to provide further context and insights.

摘要

早发性痴呆(YOD)受多种风险因素影响,包括药物滥用。在本报告中,我们介绍了一名54岁男性的病例,该患者在长期滥用苯丙胺类兴奋剂后患上了早发性痴呆。患者在寻求医疗护理前的三年时间里出现了隐匿性认知衰退。神经影像学检查显示颞叶萎缩,提示苯丙胺诱发的神经毒性与患者病情中观察到的认知异常之间存在关联。我们的病例突出了将苯丙胺类兴奋剂视为早发性痴呆潜在风险因素的重要性,并强调了识别药物滥用导致的认知障碍的必要性。此外,我们查阅了相关文献以提供更多背景信息和见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/10963994/8594c9271a76/PJMS-40-779-g001.jpg

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