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软组织肉瘤的临床人口统计学特征——来自印度东部一家三级医疗中心的5年经验

Clinico-Demographic Profile Of Soft Tissue Sarcoma- 5 Year Experience From A Tertiary Care Centre Of Eastern India.

作者信息

Biswas Linkon, Ray Anindita, De Sumitava, Biswas Koustav, Mandal Srikrishna

机构信息

Department of Radiotherapy, Nilratan Sircar Medical College and Hospital Ajc Bose Road, Kolkata, 700014 West Bengal India.

出版信息

Indian J Surg Oncol. 2024 Mar;15(Suppl 1):62-68. doi: 10.1007/s13193-023-01734-8. Epub 2023 Mar 16.

Abstract

Soft tissue sarcomas (STS) are a diverse group of malignant mesenchymal neoplasm.But, due to their low prevalence, very little data is available worldwide as well as in India regarding their clinico-epidemiological pattern.In this study we analysed the clinico-demographic profile of STS patients attending a tertiary care centre of Eastern India over the last 5 years. We analyzed the prospectively maintained database of a tertiary care centre of West Bengal in Eastern India, and collected the data regarding the demography, clinical profile, pathology and treatment of STS patients who attended our OPD between 2017-2021. The objective was to assess the demographic and clinical data of STS patients of Eastern India and compare it with those of the reported literature from rest of the country as well as outside world. Most of the cases (27%) were between 41-50 years of age group with a slight male predominance (Male: Female = 1.01:1). Spindle cell sarcoma was the most common (24.3%) histology followed by undifferentiated pleomorphic sarcoma (15%) and extremities were the most common site of involvement (47.7%). 71% patients presented with stage III and advanced disease.81% patients underwent radical surgery,14% patient received neo-adjuvant and 60% received adjuvant radiotherapy.91% patients received systemic chemotherapy. To conclude, this study is one of its first from Eastern India and will act as a stepping stone for future studies concentrating on clinico-epidemiological profile, early diagnosis and treatment of STS.

摘要

软组织肉瘤(STS)是一组多样的恶性间充质肿瘤。但是,由于其发病率低,全球以及印度关于其临床流行病学模式的数据非常少。在本研究中,我们分析了过去5年在印度东部一家三级护理中心就诊的STS患者的临床人口统计学特征。我们分析了印度东部西孟加拉邦一家三级护理中心前瞻性维护的数据库,并收集了2017年至2021年期间在我们门诊就诊的STS患者的人口统计学、临床特征、病理学和治疗数据。目的是评估印度东部STS患者的人口统计学和临床数据,并将其与该国其他地区以及世界其他地区报道的文献数据进行比较。大多数病例(27%)年龄在41至50岁之间,男性略占优势(男:女 = 1.01:1)。梭形细胞肉瘤是最常见的(24.3%)组织学类型,其次是未分化多形性肉瘤(15%),四肢是最常见的受累部位(47.7%)。71%的患者表现为III期和晚期疾病。81%的患者接受了根治性手术,14%的患者接受了新辅助治疗,60%的患者接受了辅助放疗。91%的患者接受了全身化疗。总之,本研究是来自印度东部的首批此类研究之一,将为未来专注于STS临床流行病学特征、早期诊断和治疗的研究奠定基础。

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