肢体软组织肉瘤：基于全国人口研究的描述性流行病学分析

Soft Tissue Sarcoma of Extremities: Descriptive Epidemiological Analysis According to National Population-based Study.

作者信息

Ebrahimpour Adel, Chehrassan Mohammadreza, Sadighi Mehrdad, Karimi Amin, Azizmohammad Looha Mehdi, Jafari Kafiabadi Meisam

机构信息

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Orthopedic Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Arch Bone Jt Surg. 2022 Jan;10(1):67-77. doi: 10.22038/ABJS.2021.53750.2676.

DOI:10.22038/ABJS.2021.53750.2676

PMID:35291240

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8889428/

Abstract

BACKGROUND

Soft-Tissue Sarcoma (STS) is a heterogeneous group of neoplasms of mesenchymal origin, occurring in connective tissues. According to previously conducted studies, STS accounts for approximately 1% and 7-%15% of adult and pediatric malignancies, respectively. Almost 50%-60% of sarcomas arise from extremities and usually present as a large painless or rarely painful soft-tissue mass. The present study aimed to describe the epidemiology of soft-tissue sarcomas, especially in the Iranian population.

METHODS

This epidemiological study of limb soft-tissue sarcoma was conducted based on Iran National Cancer Registry data (INCR) between 2009 and 2014. Patients with soft-tissue sarcoma confirmed by histopathological studies were included, and data were classified based on the International Classification of Diseases for Oncology (first revision-third edition [ICD-O-3]) and analyzed. Descriptive analysis was performed to extract age-standardized and age-specific incidence rates.

RESULTS

A total of 2, 593 patients (1,476 males and 1,117 females) were enrolled and assessed in the present study. The age-standardized incidence rate(ASIR) of total soft tissue sarcomas was 6.34 per million person-years. In addition, the highest and lowest ASIR scores stratified by age were observed in patients aged above 65 and under 0 with the value of 19.61 (95% CI:17.91-21.30) and 1.91 (95% CI 1.69, 2.13) per million, respectively. Limb soft tissue sarcomas stratified by gender were dominant in males, and it was statistically significant (P<0.05). The most common extremity soft tissue sarcomas subtypes were mesenchymal tumor (12.26%), spindle cell sarcoma (12.18%), and malignant fibrous histiocytoma (11.45%).

CONCLUSION

As evidenced by the results of the present study, the ASIR of soft tissue sarcoma dramatically increased with age, and the peak ASIR occurred in the age range of above 65 years. The incidence rate of soft tissue sarcomas analyzed by disease site was higher in hip and lower limb than upper limb and pelvis region, and it was detected consistently in all age groups and both genders.

摘要

背景

软组织肉瘤（STS）是一组起源于间充质的异质性肿瘤，发生于结缔组织。根据先前的研究，STS分别占成人和儿童恶性肿瘤的约1%和7%-15%。几乎50%-60%的肉瘤起源于四肢，通常表现为一个大的无痛或很少疼痛的软组织肿块。本研究旨在描述软组织肉瘤的流行病学，尤其是在伊朗人群中的情况。

方法

本肢体软组织肉瘤的流行病学研究基于2009年至2014年伊朗国家癌症登记数据（INCR）进行。纳入经组织病理学研究确诊的软组织肉瘤患者，并根据国际肿瘤疾病分类（第一版-第三版[ICD-O-3]）对数据进行分类并分析。进行描述性分析以提取年龄标准化发病率和年龄特异性发病率。

结果

本研究共纳入并评估了2593例患者（1476例男性和1117例女性）。软组织肉瘤的年龄标准化发病率（ASIR）为每百万人口年6.34例。此外，按年龄分层的最高和最低ASIR得分分别在65岁以上和0岁以下患者中观察到，每百万分别为19.61（95%CI：17.91-21.30）和1.91（95%CI 1.69，2.13）。按性别分层的肢体软组织肉瘤在男性中占主导地位，且具有统计学意义（P<0.05）。最常见的肢体软组织肉瘤亚型为间充质肿瘤（12.26%）、梭形细胞肉瘤（12.18%）和恶性纤维组织细胞瘤（11.45%）。