西咪替丁治疗胃溃疡愈合的双盲对照试验。
Double-blind controlled trial of cimetidine in the healing of gastric ulcer.
作者信息
Ciclitira P J, Machell R J, Farthing J G, Dick A P, Hunter J O
出版信息
Gut. 1979 Aug;20(8):730-4. doi: 10.1136/gut.20.8.730.
Abstract
Sixty patients with gastric ulcers were treated for four weeks with either 1 g cimetidine per day or with identical tablets containing lactose. The healing rate, assessed by endoscopy, was 23 out of 35 (66%) in the patients given cimetidine and 13 out of 25 (52%) in those given placebo. The difference between the groups is not significant. During each of the four weeks of the study the cimetidine group experienced significantly fewer attacks of pain and consumed less antacids than the placebo treated patients.
摘要
60名胃溃疡患者接受了为期四周的治疗，一组患者每天服用1克西咪替丁，另一组患者服用含乳糖的相同片剂（安慰剂）。通过内窥镜检查评估，服用西咪替丁的35名患者中有23名（66%）愈合，服用安慰剂的25名患者中有13名（52%）愈合。两组之间的差异不显著。在研究的四周中，西咪替丁组患者的疼痛发作明显少于安慰剂治疗组患者，并且服用的抗酸剂也更少。
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本文引用的文献
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Gastroenterology. 1977 May;72(5 Pt 1):838-41.
2
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Gastroenterology. 1978 Feb;74(2 Pt 2):426-30.
3
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