Sutton D R
Gut. 1982 Jul;23(7):621-4. doi: 10.1136/gut.23.7.621.
Fifty patients with endoscopically proven gastric ulcers completed a one month double-blind randomised trial of tripotassium dicitrato bismuthate (TBD) (DeNol) compared with an identical placebo. Ulcer healing occurred in 18 (72%) of the 25 patients given TDB and in nine (36%) of the patients given placebo. The TDB group experienced significantly less pain than the placebo group. During a follow-up of 29 patients with healed ulcers for up to 44 months, relapse occurred in 13 (45%). It was highest in the first three months (27%) and had risen to 41% at two years.
五十例经内镜证实为胃溃疡的患者完成了一项为期一个月的双盲随机试验,将三钾二枸橼酸铋(TBD,商品名得乐)与外观相同的安慰剂进行比较。服用TBD的25例患者中有18例(72%)溃疡愈合,服用安慰剂的患者中有9例(36%)溃疡愈合。TBD组的疼痛明显少于安慰剂组。在对29例溃疡已愈合的患者进行长达44个月的随访期间,13例(45%)出现复发。在前三个月复发率最高(27%),两年时升至41%。