Department of General Practice, Zhongnan Hospital of Wuhan University, Wuhan, China.
Int Wound J. 2024 Apr;21(4):e14858. doi: 10.1111/iwj.14858.
Hypertension is a prevalent condition that poses significant challenges in the perioperative management of patients undergoing major non-cardiac surgery, particularly concerning wound healing and scar formation. This meta-analysis assesses the impact of long-term antihypertensive treatment on postoperative wound healing, examining data from seven studies involving patients who received such treatments compared to untreated controls. Our findings reveal that long-term antihypertensive therapy is associated with significantly improved wound healing outcomes, as indicated by lower REEDA scores (I = 96%, SMD = -25.71, 95% CI: [-33.71, -17.70], p < 0.01) 1 week post-surgery and reduced scar formation, demonstrated by lower Manchester Scar Scale scores (I = 93%, SMD = -37.29, 95% CI: [-44.93, -29.64], p < 0.01) 2 months post-surgery. These results underscore the potential benefits of antihypertensive treatment in enhancing surgical recovery and offer insights into optimising perioperative care for hypertensive patients.
高血压是一种普遍存在的疾病，在接受非心脏大手术的患者的围手术期管理中带来了重大挑战，特别是在伤口愈合和疤痕形成方面。这项荟萃分析评估了长期降压治疗对术后伤口愈合的影响，分析了来自 7 项研究的数据，这些研究比较了接受此类治疗的患者与未接受治疗的对照组的情况。我们的研究结果表明，长期降压治疗与显著改善的伤口愈合结果相关，术后 1 周时 REEDA 评分较低（I = 96%，SMD = -25.71，95%CI：[-33.71，-17.70]，p < 0.01），术后 2 个月时曼彻斯特疤痕量表评分较低（I = 93%，SMD = -37.29，95%CI：[-44.93，-29.64]，p < 0.01），这表明疤痕形成减少。这些结果强调了降压治疗在促进手术康复方面的潜在益处，并为优化高血压患者的围手术期护理提供了思路。
