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产前常见精神障碍症状与不良产科和围产结局的关系:在埃塞俄比亚东部进行的一项基于社区的前瞻性队列研究。

Association between antenatal common mental disorders symptoms, and adverse obstetric and perinatal outcomes: A community-based prospective cohort study in Eastern Ethiopia.

机构信息

Department of Psychiatry, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

出版信息

J Affect Disord. 2024 Jun 15;355:31-39. doi: 10.1016/j.jad.2024.03.153. Epub 2024 Mar 27.

DOI:10.1016/j.jad.2024.03.153
PMID:38548209
Abstract

BACKGROUND

Maternal common mental disorders have broad implications for maternal and child mental and physical health that may have a long-lasting social and economic impact. This study aimed to assess the association between symptoms of antenatal common mental disorders and obstetric and perinatal outcomes in Eastern Ethiopia.

METHODS

A community-based prospective cohort study was conducted and a total of 1011 randomly selected pregnant women were followed up from February 1, 2021, to January 30, 2022. The modified Poisson regression model with a robust variance was fitted to examine the effect of the symptoms of antenatal common mental disorders on obstetric and perinatal outcomes.

RESULTS

Antenatal common mental disorders (SRQ ≥ 6) were presented among 390 (38.58 %) pregnant women. In the final multivariate Poisson regression model, women with antenatal common mental disorders symptoms had an increased risk of some pregnancy complications (ARR = 1.65, 95 % CI: 1.59, 1.84). In the current study, symptoms of antenatal common mental disorders increased also the risk of preterm birth (ARR = 1.71; 95 % CI: 1.20, 2.42) and low birth weight (ARR = 1.93; 95 % CI: 1.36, 2.74).

LIMITATION

The indirect effects of some potential mediators and moderators were not assessed in this study.

CONCLUSION

The study found a high rate of symptoms of antenatal common mental disorders and adverse obstetric and perinatal outcomes. Antenatal common mental disorders symptoms may have considerable effects on individual and combined pregnancy complications and adverse perinatal outcomes.

摘要

背景

产妇常见精神障碍对母婴身心健康有广泛影响,可能产生长期的社会和经济影响。本研究旨在评估产前常见精神障碍症状与埃塞俄比亚东部产科和围产期结局的关系。

方法

本研究采用基于社区的前瞻性队列研究,共随访了 1011 名随机选择的孕妇,随访时间从 2021 年 2 月 1 日至 2022 年 1 月 30 日。采用稳健方差修正的广义 Poisson 回归模型来检验产前常见精神障碍症状对产科和围产期结局的影响。

结果

390(38.58%)名孕妇出现产前常见精神障碍(SRQ≥6)。在最终的多变量泊松回归模型中,有产前常见精神障碍症状的女性发生某些妊娠并发症的风险增加(ARR=1.65,95%CI:1.59,1.84)。在本研究中,产前常见精神障碍症状也增加了早产(ARR=1.71;95%CI:1.20,2.42)和低出生体重(ARR=1.93;95%CI:1.36,2.74)的风险。

局限性

本研究未评估一些潜在中介和调节因素的间接效应。

结论

研究发现产前常见精神障碍症状发生率高,且产科和围产期结局不良。产前常见精神障碍症状可能对个体和综合妊娠并发症以及不良围产期结局产生重大影响。

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