College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.
College of Intelligent Systems Science and Engineering, Harbin Engineering University, Harbin 150001, China.
Int J Biol Macromol. 2024 Apr;264(Pt 2):130787. doi: 10.1016/j.ijbiomac.2024.130787. Epub 2024 Mar 27.
In present study, polysaccharide polyelectrolyte nanoparticles (CMAAP-CS NPs) were constructed by mixing carboxymethylated Anemarrhena asphodeloides polysaccharide (CMAAP) and chitosan (CS). CMAAP-CS NPs were applied as carrier to improve the bioavailability and stability of curcumin (Cur). The average particle size of CMAAP-CS NPs was 216.60 ± 4.21 nm and the entrapment efficiency of Cur reached 82.50 ± 2.09 %. The simulated digestion experiments in vitro confirmed that the bioavailability of Cur loaded in CMAAP-CS NPs was 59.84 ± 0.03 % after saliva, gastric and intestinal digestion, which was obvious higher than 21.57 ± 0.07 % of free Cur under the same conditions. The results of stability testing revealed that CMAAP-CS NPs could markedly reduce the degradation of Cur against storage, heating, UV light treatment, and neutral pH. This study provided promising polyelectrolyte complex loaded hydrophobic nutrients in medicine industry.
在本研究中，通过混合羧甲基地黄多糖（CMAAP）和壳聚糖（CS）构建了多糖聚电解质纳米粒子（CMAAP-CS NPs）。CMAAP-CS NPs 被用作载体来提高姜黄素（Cur）的生物利用度和稳定性。CMAAP-CS NPs 的平均粒径为 216.60±4.21nm，Cur 的包封率达到 82.50±2.09%。体外模拟消化实验证实，经过唾液、胃和肠消化后，负载在 CMAAP-CS NPs 中的 Cur 的生物利用度为 59.84±0.03%，明显高于相同条件下游离 Cur 的 21.57±0.07%。稳定性测试结果表明，CMAAP-CS NPs 可以显著降低 Cur 在储存、加热、紫外光处理和中性 pH 下的降解。这项研究为医药行业中负载疏水性营养物的聚电解质复合物提供了有前景的方法。
