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信息素为基础的通讯影响秀丽隐杆线虫体细胞细胞外囊泡的产生。

Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans.

机构信息

Laboratory of Animal Molecular Physiology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.

出版信息

Nat Commun. 2024 Mar 28;15(1):2715. doi: 10.1038/s41467-024-47016-x.

DOI:10.1038/s41467-024-47016-x
PMID:38548742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10978837/
Abstract

Extracellular vesicles (EVs) are integral to numerous biological processes, yet it is unclear how environmental factors or interactions among individuals within a population affect EV-regulated systems. In Caenorhabditis elegans, the evolutionarily conserved large EVs, known as exophers, are part of a maternal somatic tissue resource management system. Consequently, the offspring of individuals exhibiting active exopher biogenesis (exophergenesis) develop faster. Our research focuses on unraveling the complex inter-tissue and social dynamics that govern exophergenesis. We found that ascr#10, the primary male pheromone, enhances exopher production in hermaphrodites, mediated by the G-protein-coupled receptor STR-173 in ASK sensory neurons. In contrast, pheromone produced by other hermaphrodites, ascr#3, diminishes exophergenesis within the population. This process is regulated via the neuropeptides FLP-8 and FLP-21, which originate from the URX and AQR/PQR/URX neurons, respectively. Our results reveal a regulatory network that controls the production of somatic EV by the nervous system in response to social signals.

摘要

细胞外囊泡 (EVs) 是许多生物学过程的重要组成部分，但目前尚不清楚环境因素或群体中个体之间的相互作用如何影响 EV 调节的系统。在秀丽隐杆线虫中，进化上保守的大型 EV，称为外体，是母体体细胞组织资源管理系统的一部分。因此，表现出活跃外体生物发生 (exophergenesis) 的个体的后代发育得更快。我们的研究重点是揭示支配外体生物发生的复杂组织间和社会动态。我们发现，主要的雄性信息素 asc#10 通过 ASK 感觉神经元中的 G 蛋白偶联受体 STR-173 增强了雌雄同体中的外体产生，而其他雌雄同体产生的信息素 asc#3 则减少了群体中的外体生物发生。这个过程是通过来自 URX 和 AQR/PQR/URX 神经元的神经肽 FLP-8 和 FLP-21 来调节的。我们的结果揭示了一个调节网络，该网络通过神经系统响应社会信号来控制体细胞 EV 的产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/eb89a48eed28/41467_2024_47016_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/d3f229d42b77/41467_2024_47016_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/f3ec647aeabe/41467_2024_47016_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/6dfa4004931a/41467_2024_47016_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/d52fff700d1d/41467_2024_47016_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/1fe957c29441/41467_2024_47016_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/9ef4c1a4d5bb/41467_2024_47016_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/f97b5b3dc134/41467_2024_47016_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/eb89a48eed28/41467_2024_47016_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/d3f229d42b77/41467_2024_47016_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/f3ec647aeabe/41467_2024_47016_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/6dfa4004931a/41467_2024_47016_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/d52fff700d1d/41467_2024_47016_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/1fe957c29441/41467_2024_47016_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/9ef4c1a4d5bb/41467_2024_47016_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/f97b5b3dc134/41467_2024_47016_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ce9/10978837/eb89a48eed28/41467_2024_47016_Fig8_HTML.jpg

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2
Preparation of for Scoring of Muscle-derived Exophers.用于肌肉源性外显子评分的准备工作。
Bio Protoc. 2023 Jan 5;13(1). doi: 10.21769/BioProtoc.4586.
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4
Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.不同的状态和刺激会调节嗅觉受体的表达水平，从而调节觅食行为。
Elife. 2022 Aug 31;11:e79557. doi: 10.7554/eLife.79557.
5
Male-female communication enhances release of extracellular vesicles leading to high fertility in Drosophila.雌雄间的交流增强了细胞外囊泡的释放，从而提高了果蝇的生育能力。
Commun Biol. 2022 Aug 13;5(1):815. doi: 10.1038/s42003-022-03770-6.
6
A male pheromone that improves the quality of the oogenic germline.一种能改善卵子生殖细胞质量的雄性信息素。
Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2015576119. doi: 10.1073/pnas.2015576119. Epub 2022 May 16.
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