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逐拍血压监测仪的研制及夜间二次收缩压探测算法的开发。

Development of beat-by-beat blood pressure monitoring device and nocturnal sec-surge detection algorithm.

机构信息

Omron Healthcare Co., Ltd., Kyoto, Japan.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

出版信息

Hypertens Res. 2024 Jun;47(6):1576-1587. doi: 10.1038/s41440-024-01631-9. Epub 2024 Mar 28.

DOI:10.1038/s41440-024-01631-9
PMID:38548911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11150154/
Abstract

The nocturnal blood pressure (BP) surge in seconds (sec-surge) is defined as a brief, acute transient BP elevation over several tens of seconds, triggered by obstructive sleep apnea (OSA) and sympathetic hyperactivity. Sec-surge imposes a significant strain on the cardiovascular system, potentially triggering cardiovascular events. Quantitative evaluation of sec-surge level could be valuable in assessing cardiovascular risks. To accurately measure the detailed sec-surge, including its shape as BP rises and falls, we developed a beat-by-beat (BbB) BP monitoring device using tonometry. In addition, we developed an automatic sec-surge detection algorithm to help identify sec-surge cases in the overnight BbB BP data. The device and algorithm successfully detected sec-surges in patients with OSA. Our results demonstrated that sec-surge was associated with left ventricular hypertrophy and arterial stiffness independently of nocturnal BP level or variability. Sec-surge would be worth monitoring for assessing cardiovascular risks, in addition to nocturnal BP level. Nocturnal blood pressure (BP) surge in seconds (sec-surge) places heavy load on the cardiovascular system and can trigger cardiovascular events. To identify sec-surges, we developed a beat-by-beat BP monitoring device and a sec-surge detection algorithm. Furthermore, sec-surge was more related to cardiovascular risks than conventional nocturnal BP parameters.

摘要

秒级夜间血压（BP）飙升是指由阻塞性睡眠呼吸暂停（OSA）和交感神经活性引起的数十秒内短暂、急性的 BP 升高。秒级夜间血压（BP）飙升会对心血管系统造成很大的压力，可能会引发心血管事件。定量评估秒级夜间血压（BP）飙升水平有助于评估心血管风险。为了准确测量详细的秒级夜间血压（BP）飙升情况，包括 BP 上升和下降的形态，我们使用眼压计开发了一种逐拍（beat-by-beat，BbB）BP 监测设备。此外，我们开发了一种自动秒级夜间血压（BP）飙升检测算法，以帮助识别 overnight BbB BP 数据中的秒级夜间血压（BP）飙升病例。该设备和算法成功地检测到了 OSA 患者的秒级夜间血压（BP）飙升。我们的结果表明，秒级夜间血压（BP）飙升与左心室肥厚和动脉僵硬独立于夜间 BP 水平或变异性相关。除了夜间 BP 水平外，监测秒级夜间血压（BP）飙升对于评估心血管风险也很有价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/162af68386fc/41440_2024_1631_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/1ee24496c03b/41440_2024_1631_Figa_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/62ce7372341b/41440_2024_1631_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/2f9b3fc32e7a/41440_2024_1631_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/6c5f2c6afb27/41440_2024_1631_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/b139218a0ebd/41440_2024_1631_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/e6d6c6aa2fd4/41440_2024_1631_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/162af68386fc/41440_2024_1631_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/1ee24496c03b/41440_2024_1631_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/e4838ea05d1a/41440_2024_1631_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/62ce7372341b/41440_2024_1631_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/d322f9e22d1a/41440_2024_1631_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/2f9b3fc32e7a/41440_2024_1631_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/6c5f2c6afb27/41440_2024_1631_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/b139218a0ebd/41440_2024_1631_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/e6d6c6aa2fd4/41440_2024_1631_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd2/11150154/162af68386fc/41440_2024_1631_Fig8_HTML.jpg

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