School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Environ Pollut. 2023 Oct 15;335:122295. doi: 10.1016/j.envpol.2023.122295. Epub 2023 Jul 31.
Bisphenol A (BPA) is an endocrine-disrupting chemical substance responsible for the composition of polycarbonate plastics and epoxy resins. Early life and pregnancy are important windows of susceptibility. This review aimed to conduct a systematic assessment of human studies to comprehensively describe the association between prenatal BPA exposure and neonatal health outcomes. Literature was searched in Cochrane Library, Embase, PubMed, Scopus, and Web of Science published before November 2022, and were selected according to clear inclusion and exclusion criteria. The Newcastle-Ottawa scale (NOS) and Grades of Recommendation, Assessment, Development, and Evaluation guidelines (GRADE) were followed to grade the methodological quality of studies and the certainty of the evidence respectively. As a result, a total of 22259 participants from 45 trials were included. And the potential associations of prenatal exposure to BPA and neonatal health outcomes were mainly shown in four aspects: gestational age/preterm birth, physical health at birth, the incidence of systemic abnormalities or diseases, and other health outcomes. Although the certainty of the evidence was low to very low, the methodological quality of the included studies was high. Prenatal BPA exposure tended to have negative effects on most of the health outcomes in neonates but showed inconsistent results on physical health at birth. This systematic review is the first to comprehensively synthesize the existing evidence on the association between prenatal BPA exposure and neonatal health outcomes. In the future, further studies are still needed to verify these effects and elucidate the underlying mechanisms.
双酚 A（BPA）是一种内分泌干扰化学物质，用于合成聚碳酸酯塑料和环氧树脂。生命早期和妊娠是易感性的重要窗口。本综述旨在对人类研究进行系统评估，全面描述产前 BPA 暴露与新生儿健康结局之间的关系。在 Cochrane Library、Embase、PubMed、Scopus 和 Web of Science 中搜索了截至 2022 年 11 月之前发表的文献，并根据明确的纳入和排除标准进行了选择。采用纽卡斯尔-渥太华量表（NOS）和推荐、评估、开发和评估分级（GRADE）分别对研究的方法学质量和证据的确定性进行分级。结果共纳入 45 项试验的 22259 名参与者。产前暴露于 BPA 与新生儿健康结局的潜在关联主要表现在四个方面：胎龄/早产、出生时的身体健康、全身异常或疾病的发生率以及其他健康结局。尽管证据的确定性为低至极低，但纳入研究的方法学质量较高。产前 BPA 暴露往往对大多数新生儿的健康结局产生负面影响，但对出生时的身体健康结果显示不一致。本系统综述是首次全面综合现有的关于产前 BPA 暴露与新生儿健康结局之间关系的证据。未来仍需要进一步的研究来验证这些影响，并阐明潜在的机制。
