Maitrya B B, Gahlot S, Maitrya B
Indian J Physiol Pharmacol. 1979 Apr-Jun;23(2):105-9.
Shay rats and conscious rabbits were used to study the effect of sex hormones on gastric secretion. Daily injections of estradiol-di propionate and testosterone-propionate were given separately to each set of animals, while the control animals received solvent alone for the same duration of time. Estrogen inhibited gastric acid output but augmented the mucus secretion as evidenced by increased hexosamine and fucose contents; and testosterone had the reverse effects. The effect of estrogen was more potent that of testosterone. An inverse relationship between gastric acid and mucus secretion has been noted. Peptic activity varied independently of the acid output. These hormones seemed to vary the acid output by modifying the composition of mucus secretion.
采用 Shay 大鼠和清醒家兔研究性激素对胃液分泌的影响。分别对每组动物每日注射二丙酸雌二醇和丙酸睾酮，而对照动物在相同时间段内仅接受溶剂。雌激素抑制胃酸分泌，但增加黏液分泌，这可通过己糖胺和岩藻糖含量增加得以证明；而睾酮则产生相反的作用。雌激素的作用比睾酮更强。已观察到胃酸与黏液分泌之间呈负相关。胃蛋白酶活性与酸分泌无关。这些激素似乎通过改变黏液分泌的组成来改变酸分泌。
