Kristensen M, Nilsson T
Am J Gastroenterol. 1985 Feb;80(2):77-81.
A 48-year-old man presented with giant folds of the gastric mucosa, hypoalbuminemia, and hypersecretion of acid. In vivo labeling of plasma proteins by 51CrCl3 disclosed an abnormal gastric protein clearance. Mucus secretion, evaluated by the output of dry matter, mucosubstance constituents (hexosamine and fucose), protein (by the method of Lowry), and sodium were five to eight times those in nine healthy volunteers, but were normalized by the histamine-H2-receptor antagonist cimetidine. The proportion of dry matter and protein was the same in the patient and in healthy subjects, indicating that the loss of plasma protein into the stomach probably occurred as part of an abnormally great secretion of mucus.
一名48岁男性出现胃黏膜巨大皱襞、低白蛋白血症和胃酸分泌过多。用51CrCl3对血浆蛋白进行体内标记显示胃蛋白清除异常。通过干物质输出、黏膜物质成分（己糖胺和岩藻糖）、蛋白质（采用洛瑞法）和钠来评估黏液分泌，该患者的这些指标是9名健康志愿者的5至8倍，但组胺H2受体拮抗剂西咪替丁可使其恢复正常。患者和健康受试者的干物质和蛋白质比例相同，这表明血浆蛋白进入胃内可能是黏液异常大量分泌的一部分。
