Levitan Emily B, Poudel Bharat, Huang Lei, Zhao Hong, Bittner Vera, Safford Monika M, Jackson Elizabeth A, Monda Keri L, Muntner Paul
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Am Heart J Plus. 2021 Jul 30;7:100036. doi: 10.1016/j.ahjo.2021.100036. eCollection 2021 Jul.
To determine whether recurrent myocardial infarction (MI) is associated with increased risk of mortality, long-term nursing home placement, and impoverishment.
Retrospective cohort study.
United States Medicare program.
Individuals age > 65 years with recurrent MI hospitalizations ( = 228,826) between January 1, 2007 and June 30, 2017 and controls with initial but not recurrent MI ( = 915,304).
Death, nursing home placement, and impoverishment (Medicaid enrollment or subsidies for low-income and -resource individuals) through December 31, 2017.
In the recurrent MI and control cohorts, 47% and 41% of individuals were age > 80 years, respectively, and 56% of both cohorts were women. After 1 year, 48% of the recurrent MI cohort and 16% of the control cohort died, 9% and 7% experienced nursing home placement, and 4% and 2% experienced impoverishment. Multivariable-adjusted hazard ratios (95% confidence intervals) comparing the recurrent MI and control cohorts were 2.04 (2.03-2.06) for death, 0.89 (0.88-0.91) for nursing home placement, and 1.32 (1.28-1.36) for impoverishment.
Older US adults with recurrent MI had higher risk of death and impoverishment than controls who had experienced an initial MI. Unadjusted, recurrent MI was associated with higher risk of nursing home placement; however, after adjusting for sociodemographic characteristics and comorbidities, individuals with recurrent MI had slightly lower risk of nursing home placement. Preventing recurrent MI may also reduce the risk of death and impoverishment among older US adults.
确定复发性心肌梗死(MI)是否与死亡风险增加、长期入住养老院及贫困相关。
回顾性队列研究。
美国医疗保险计划。
2007年1月1日至2017年6月30日期间有复发性MI住院记录的65岁以上个体(n = 228,826)以及初次发生但非复发性MI的对照个体(n = 915,304)。
截至2017年12月31日的死亡、入住养老院及贫困情况(医疗补助登记或针对低收入和资源匮乏个体的补贴)。
在复发性MI队列和对照队列中,分别有47%和41%的个体年龄大于80岁,两个队列中均有56%为女性。1年后,复发性MI队列中有48%的个体死亡,对照队列中有16%的个体死亡;9%的复发性MI队列个体和7%的对照队列个体入住养老院;4%的复发性MI队列个体和2%的对照队列个体陷入贫困。比较复发性MI队列和对照队列的多变量调整风险比(95%置信区间),死亡风险比为2.04(2.03 - 2.06),入住养老院风险比为0.89(0.88 - 0.91),贫困风险比为1.32(1.28 - 1.36)。
患有复发性MI的美国老年人比经历过初次MI的对照个体有更高的死亡和贫困风险。未经调整时,复发性MI与入住养老院的风险较高相关;然而,在调整社会人口学特征和合并症后,复发性MI个体入住养老院的风险略低。预防复发性MI也可能降低美国老年人的死亡和贫困风险。