Yoneda Akira, Ogata Ryosuke, Ryu Shintaro, Yoshino Kyohei, Fukui Saeko, Ikeda Takahiro, Kitasato Amane, Sugiyama Nozomu, Takeshita Hiroaki, Minami Shigeki, Ito Masahiro, Kuroki Tamotsu
Department of Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Department of Pathology, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Case Rep Gastroenterol. 2024 Mar 28;18(1):189-194. doi: 10.1159/000538161. eCollection 2024 Jan-Dec.
Primary malignant melanoma of the esophagus is a very rare disease with a poor prognosis. We herein report a patient with primary malignant melanoma of the esophagus who underwent surgical resection.
A 73-year-old female underwent an upper gastrointestinal endoscopy during follow-up for colonic diverticulitis. An endoscopic examination and constructed radiography revealed a slightly elevated black pigmented lesion in the upper esophagus and a black pigmented area in the esophagogastric junction. Through a preoperative endoscopic biopsy, she was diagnosed with malignant melanoma of the esophagus. We performed thoracoscopy-assisted and laparoscopy-assisted subtotal esophagectomy with lymphadenectomy. The surgical specimens were subjected to immunohistochemical analysis, resulting in a diagnosis of malignant melanoma. The tumor cells were positive for Melan-A and HMB-45 diffusely, supporting that diagnosis. We performed surgical resection in a case of primary malignant melanoma of the esophagus, and the patient has remained disease free for 2 years since the surgery.
Early diagnosis and radical resection may be essential for long-term survival in patients with malignant melanoma of the esophagus.
原发性食管恶性黑色素瘤是一种非常罕见的疾病，预后较差。我们在此报告一例接受手术切除的原发性食管恶性黑色素瘤患者。
一名73岁女性在因结肠憩室炎进行随访期间接受了上消化道内镜检查。内镜检查和造影显示食管上段有一个略隆起的黑色色素沉着病变，食管胃交界处有一个黑色色素沉着区域。通过术前内镜活检，她被诊断为食管恶性黑色素瘤。我们进行了胸腔镜辅助和腹腔镜辅助的食管次全切除术及淋巴结清扫术。手术标本进行了免疫组织化学分析，结果诊断为恶性黑色素瘤。肿瘤细胞Melan-A和HMB-45弥漫性阳性，支持该诊断。我们对一例原发性食管恶性黑色素瘤患者进行了手术切除，患者自手术以来已无病生存2年。
早期诊断和根治性切除对于食管恶性黑色素瘤患者的长期生存可能至关重要。
