[具体物质]在痤疮中的作用及异维A酸对[具体物质]表达的影响。 （注：原文中“Role of in Acne”和“Effect of Isotretinoin on Expression”两处的“ ”指代不明，需根据实际情况补充完整后准确翻译）
Role of in Acne and Effect of Isotretinoin on Expression.
作者信息
Kamboj Parul, Khullar Geeti, Handa Sanjeev, Pal Arnab, Saikia Uma Nahar, De Dipankar
机构信息
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Indian Dermatol Online J. 2024 Feb 28;15(2):252-254. doi: 10.4103/idoj.idoj_455_23. eCollection 2024 Mar-Apr.
BACKGROUND
Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor () and role of isotretinoin in improving acne via modulating this pathway.
AIM
To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of , peroxisome proliferator-activated receptor (), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.
RESULTS
The gene expression of was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in expression in acne patients at mRNA ( = 0.05) level was observed. There was a significant decrease in grade 3 positivity of at protein level ( = 0.0009). A decrease in androgen receptor positivity ( = 0.055) at protein level was also observed.
CONCLUSION
Reduction in expression appears to be an important mechanism of action of isotretinoin in acne.
背景
结节囊肿性痤疮是一种严重的痤疮类型，已知用异维甲酸治疗后会改善。梅尔尼克提出了一个关于痤疮发病机制的统一概念，涉及叉头框O转录因子（）表达的改变以及异维甲酸通过调节该途径改善痤疮的作用。
目的
通过分析痤疮患者与非痤疮对照之间、、过氧化物酶体增殖物激活受体（）和雄激素受体（AR）表达的差异，以及异维甲酸治疗对痤疮患者这些基因表达变化的影响，来评估梅尔尼克提出的痤疮发病机制途径。
结果
与对照组相比，痤疮患者中基因的表达无显著升高。用异维甲酸治疗后，观察到痤疮患者在mRNA（=0.05）水平上的表达显著下降。在蛋白质水平上，的3级阳性率显著下降（=0.0009）。在蛋白质水平上也观察到雄激素受体阳性率下降（=0.055）。
结论
表达的降低似乎是异维甲酸治疗痤疮的一个重要作用机制。
Zotero 插件