Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chemosphere. 2024 May;355:141825. doi: 10.1016/j.chemosphere.2024.141825. Epub 2024 Mar 27.
Most research exploring the correlation between volatile organic compounds (VOCs) and hematological parameters have focused on single VOCs. Our study aimed to explore the single and combined effects of VOCs on hematological parameters through three statistical models.
Data from 4 cycles of the National Health and Nutrition Examination Survey (NHANES) were used in this study. The correlations between single exposure to 16 VOCs and hematological parameters in the general population were assessed by weighted multiple linear regression. Weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models were used to explore the relationship between the combined important VOCs selected by the least absolute shrinkage and selection operator (LASSO) and hematological parameters, as well as the effects of smoking status on them.
A total of 4089 adults were included in the study. We found that a variety of VOCs were significantly associated with hematological parameters. Among them, N-acetyl-S-(benzyl)-l-cysteine (BMA) was significantly negatively correlated with white blood cell (WBC), red blood cell (RBC), lymphocyte, and neutrophil counts. N-acetyl-S-(3-hydroxypropyl-1-methyl)-l-cysteine (HPMMA) was significantly positively correlated with WBC, monocyte, lymphocyte, and neutrophil counts. In the WQS analysis, the WQS index of the VOCs mixtures was positively correlated with WBC (β: 0.031; P < 0.001), monocyte (0.023; P = 0.021), and neutrophil (0.040; P = 0.001) counts, while negatively associated with RBC (-0.013; P < 0.001) counts. The BKMR model revealed that combined exposure to VOCs levels ≥70th percentile was significantly associated with lower RBC counts, and BMA was identified as the dominant contributor. Smoking significantly influenced the relationship between VOCs and hematological parameters.
Our study indicated the effects of single and overall VOCs exposure on hematological parameters and suggested the hematotoxicity as well as pro-inflammatory effects of VOCs, which had strong public health implications for reducing the potential health hazards of VOCs exposure to the hematologic system.
大多数探索挥发性有机化合物（VOCs）与血液学参数之间相关性的研究都集中在单一 VOC 上。我们的研究旨在通过三个统计模型探索 VOC 对血液学参数的单一和综合影响。
本研究使用了 4 轮全国健康和营养检查调查（NHANES）的数据。通过加权多元线性回归评估了一般人群中 16 种单一 VOC 暴露与血液学参数之间的相关性。加权分位数总和（WQS）和贝叶斯核机器回归（BKMR）模型用于探索由最小绝对收缩和选择算子（LASSO）选择的重要 VOC 组合与血液学参数之间的关系，以及吸烟状况对它们的影响。
共有 4089 名成年人纳入研究。我们发现，多种 VOC 与血液学参数显著相关。其中，N-乙酰-S-（苄基）-L-半胱氨酸（BMA）与白细胞（WBC）、红细胞（RBC）、淋巴细胞和中性粒细胞计数呈显著负相关。N-乙酰-S-（3-羟基丙基-1-甲基）-L-半胱氨酸（HPMMA）与 WBC、单核细胞、淋巴细胞和中性粒细胞计数呈显著正相关。在 WQS 分析中，VOC 混合物的 WQS 指数与 WBC（β：0.031；P<0.001）、单核细胞（0.023；P=0.021）和中性粒细胞（0.040；P=0.001）计数呈正相关，而与 RBC（-0.013；P<0.001）计数呈负相关。BKMR 模型显示，VOC 水平≥第 70 百分位数的联合暴露与 RBC 计数较低显著相关，BMA 被确定为主要贡献者。吸烟显著影响了 VOC 与血液学参数之间的关系。
本研究表明了单一和总体 VOC 暴露对血液学参数的影响，并提示了 VOC 的血液毒性和促炎作用，这对减少 VOC 暴露对血液系统潜在健康危害具有重要的公共卫生意义。
